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However, the specific role of matrisome during this process remains largely undefined. We perform integrated\u00a0transcriptomic and proteomic analyses\u00a0of prepubertal mouse ovaries to delineate the dynamics of the matrisome during EFD. Cross\u2010species comparison reveals a significant enrichment of matrisome\u2010associated items in mice, sheep, and pigs. We employ instrumental nanoindentation and Raman spectroscopy to obtain mechanical, topographical, and biochemical spectral data. And integrin \u03b1v\u03b23 is identified as a critical receptor mediating matrisome signals to follicles. Functional inhibition of \u03b1v\u03b23 exhibits a dual effect: it promotes primordial follicle activation, yet concurrently induces follicular atresia. Moreover, disruption of matrisome signals hinders secondary follicles growth by attenuating the cytoskeletal integrity and viability of granulosa cells; it also compromises oocyte maturation by disturbing the meiosis progression and mitochondrial function. Importantly, the role of matrisome is underscored in\u00a0human ovarian tissues, which exhibited similar collagen remodeling and stage\u2010specific \u03b1v\u03b23 expression. Collectively, our work constructs a multi\u2010dimensional atlas of matrisome during EFD and determines \u03b1v\u03b23 as a pivotal mediator of matrisome\u2010follicle crosstalk, offering mechanistic insights into ovarian dysfunction and impaired follicular development.<\/jats:p>","DOI":"10.1002\/advs.202507314","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:21:43Z","timestamp":1773516103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ovarian Matrisome Dynamics and \u03b1v\u03b23\u2010Mediated Regulation in Early Follicular Development"],"prefix":"10.1002","volume":"13","author":[{"given":"Tong","family":"Wu","sequence":"first","affiliation":[{"name":"National Clinical Research Center For Obstetrical and Gynecological Diseases Tongji Hospital Huazhong University of Science and Technology  Wuhan P. R. 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