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Although these therapies show promise in arresting disease progression and improving vision, intraocular implant\u2010based therapies can cause unexpected complications that require further surgery due to implant dislocation or uncontrolled drug release. These frequent complications of intraocular drug implants can be overcome using magnetically controllable degradable milliscale swimmers (MDMS) with a double\u2010helix body morphology. A biodegradable hydrogel, polyethylene glycol diacrylate, is employed as the primary 3D printing material of MDMS, and it is magnetized by decorating it with biocompatible polydopamine\u2010encapsulated iron\u2010platinum nanoparticles. MDMS have comparable dimensions to commercial intraocular implants that achieve translational motions in both aqueous and vitreous bodies. They can be imaged in real\u2010time using optical coherence tomography, ultrasound, and photoacoustic imaging. Thanks to their biodegradable hydrogel\u2010based structure, they can be loaded with anti\u2010inflammatory drug molecules and release the medications without disrupting retinal epithelial viability and barrier function, and decrease proinflammatory cytokine release significantly. These magnetically controllable swimmers, which degrade in a couple of months, can be used for less invasive and more precise intraocular drug delivery compared to commercial intraocular drug implants.<\/jats:p>","DOI":"10.1002\/advs.202507569","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T10:10:51Z","timestamp":1751191851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Magnetically Controllable and Degradable Milliscale Swimmers as Intraocular Drug Implants"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-3524","authenticated-orcid":false,"given":"Erdost","family":"Yildiz","sequence":"first","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  Stuttgart Germany"},{"name":"Ko\u00e7 University Research Center for Translational Medicine (KUTTAM) Ko\u00e7 University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-2307","authenticated-orcid":false,"given":"Ugur","family":"Bozuyuk","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eray","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  Stuttgart Germany"},{"name":"Department of Molecular Biology and Genetics Izmir Institute of Technology  Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  Stuttgart Germany"},{"name":"Institute for Biomedical Engineering ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mertcan","family":"Han","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  Stuttgart Germany"},{"name":"Institute for Biomedical Engineering ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp Can","family":"Karacakol","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Sitti","sequence":"additional","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  Stuttgart Germany"},{"name":"Ko\u00e7 University Research Center for Translational Medicine (KUTTAM) Ko\u00e7 University  Istanbul Turkey"},{"name":"School of Medicine and College of Engineering Ko\u00e7 University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.695904"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.04.027"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.09.010427"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-0809-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S138922"},{"key":"e_1_2_10_7_1","first-page":"139","volume":"5","author":"Herrero\u2010Vanrell R.","year":"2011","journal-title":"Clin. 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