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This review evaluates the role of lipid\u2010based nanoparticles (LNPs), including liposomes, micelles, nanoemulsions, solid lipid nanoparticles, and nanostructured lipid carriers, as advanced drug delivery systems in providing innovative solutions for RCC diagnosis and treatment. These LNPs exhibit unique advantages of great biocompatibility, biodegradability, extended circulation, and tumor\u2010targeting capabilities, which enable precise drug delivery, controlled release, and circumvention of drug resistance mechanisms. After integrating recent advancements, it is highlighted that formulations such as Liposome@Sunitinib can enhance tumor accumulation, two\u2010drug\u2010loaded liposomes can activate immune responses, and RNA therapy in combination with immunomodulators can reverse drug resistance. Current findings underscore the transformative potential of lipid\u2010based nanotechnology in addressing RCC\u2010specific challenges, particularly in overcoming biological barriers and refining personalized treatment approaches. 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