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These small proteins or micropeptides can function independently or exert their biological functions by binding to and\/or regulating larger regulatory proteins. LSMEM1 (leucine rich single\u2010pass membrane protein 1, also known as C7orf53) has been found to be significantly upregulated in chronic kidney disease (CKD). In the present study, the molecular structure is aimed to elucidate and function of LSMEM1 and dissect its implications both in physiological and pathophysiological condition. Single\u2010cell transcriptome sequencing (scRNA\u2010seq) technology is used to examine the transcriptional state and biological processes of Lsmem1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice kidneys. Experiments are conducted to verify these biological processes in both physiological and disease states. LSMEM1 is associated with cell injury, inflammation and lipid metabolism. Further, LSMEM1 plays a critical role in delaying\u00a0CKD progression through regulating lipid droplet accumulation in proximal tubular epithelial cells. This study explores the function of the small protein LSMEM1 in physiological and disease development. LSMEM1 may be a novel revenue for targeted therapy for CKD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202507713","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:16:12Z","timestamp":1756289772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2069-8391","authenticated-orcid":false,"given":"Peimin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou 510080 China"},{"name":"Guangdong\u2010Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases Guangdong Provincial People's Hospital (Guangdong 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