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Although hydrogels offer significant potential for facilitating biomedical applications of enzymes due to their flexibility, macroscopic processability, and extracellular matrix\u2010like properties. However, maintaining enzymatic activity and recyclability within bulk hydrogels remains a formidable challenge due to restricted passive mass transfer and enzyme leakage. Herein, inspired by the heart's blood\u2010pumping mechanism, a smart metal\u2013organic framework (MOFs)\u2010doped hydrogel is developed for enzyme immobilization to effectively address these challenges. Importantly, thermally triggered contraction\/expansion cycles of the hydrogel, coupled with a dynamic water stream, significantly enhance substrates\u00a0intake and endogenous products expulsion, while enzymes are effectively retained due to the interception effect of MOFs. This activity can be tuned by adjusting hydrogel contractility, enabling active mass transfer and regeneration similar to living tissues. Benefit from these advantages, the biosystems perform well in biosensing applications. This study provides a novel solution for enzymatic immobilization in porous 3D matrices and opens opportunities for the construction of life\u2010like bio\u2010microdevices or artificial organelles.<\/jats:p>","DOI":"10.1002\/advs.202507886","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T10:06:08Z","timestamp":1764410768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Smart Hydrogel Doped by Metal\u2013Organic Frameworks for Renewable Self\u2010Pumping Enzymatic Reactors"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuxi","family":"Zhu","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Life and Health Detection Life and Health Intelligent Research Institute Tianjin University of Technology  Tianjin 300384 P. R. 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