{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:45:21Z","timestamp":1790671521512,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"46","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22276112"],"award-info":[{"award-number":["22276112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Industrial hydrogenation is a pivotal process in chemical synthesis. However, it has significant drawbacks, including high cost, safety risks associated with the use of molecular hydrogen gas, and substantial energy demands due to the need for elevated temperatures and pressures to achieve satisfactory yields. The borrowing hydrogen synthesis, which enables the transfer of hydrogen between molecules, offers a promising approach for green, one\u2010pot synthesis of industrially important chemicals and intermediates. Despite its potential, the broad application remains limited due to the reliance on toxic solvents, expensive noble metal catalysts, and the still restricted efficiency and substrate scope. In this study, the first solvent\u2010free strategy for the\n                    <jats:italic>N<\/jats:italic>\n                    \u2010alkylation of amines with alcohols is presented, employing an N\u2010doped graphene\u2010supported Fe single\u2010atom catalyst (Fe\n                    <jats:sub>SA<\/jats:sub>\n                    @N\u2010G; 1.06 wt.%). This approach achieves superior conversion and selectivity (up to 99%) along with record values for turnover number (TON, 1032.7) and turnover frequency (TOF, 413.1 h\n                    <jats:sup>-1<\/jats:sup>\n                    ) for the coupling reaction of aniline with benzyl alcohol, surpassing all previously reported catalysts. DFT calculations, combined with experimental data, elucidated the reaction mechanism and identified the Fe\n                    <jats:sub>1<\/jats:sub>\n                    (III)\u2010N\n                    <jats:sub>4<\/jats:sub>\n                    active site participating in Fe\u2010H hydride transfer and containing two pyrrolic and two pyridinic nitrogens bound to the Fe center. The developed technology is further supported by the catalyst's excellent scalability, reusability, and performance under continuous\u2010flow conditions. Additionally, the exceptional efficiency of the single\u2010atom catalyst is demonstrated across more than 50 substrates, including reactions involving both aliphatic and aromatic amines with aliphatic and aromatic alcohols. The industrial applicability of this technology is validated through the synthesis of pharmaceutically relevant compounds, including stimulant drugs, antihistamines, and pharmaceutical intermediates.\n                  <\/jats:p>","DOI":"10.1002\/advs.202507915","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:11:12Z","timestamp":1755601872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Iron Single\u2010Atom Catalyzed N\u2010Alkylation of Amines with Alcohols via Solvent\u2010Free Borrowing Hydrogen Strategy"],"prefix":"10.1002","volume":"12","author":[{"given":"Arun D.","family":"Kute","sequence":"first","affiliation":[{"name":"Department of Industrial and Engineering Chemistry Institute of Chemical Technology Mumbai\u2010 Marathwada Campus  Jalna Maharashtra 431213 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanumant B.","family":"Kale","sequence":"additional","affiliation":[{"name":"Department of Industrial and Engineering Chemistry Institute of Chemical Technology Mumbai\u2010 Marathwada Campus  Jalna Maharashtra 431213 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute Palack\u00fd University  Olomouc 27 \u0160lechtitel\u016f 779 00 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasu","family":"Kancharlapalli","sequence":"additional","affiliation":[{"name":"Chemistry Division Bhabha Atomic Research Centre Mumbai 400085 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajanan Y.","family":"Shinde","sequence":"additional","affiliation":[{"name":"Department of Industrial and Engineering Chemistry Institute of Chemical Technology Mumbai\u2010 Marathwada Campus  Jalna Maharashtra 431213 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Organic Synthesis and Process Chemistry CSIR\u2010Indian Institute of Chemical Technology  Hyderabad 500007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Organic Synthesis and Process Chemistry CSIR\u2010Indian Institute of Chemical Technology  Hyderabad 500007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Davidson School of Chemical Engineering Purdue University  480 Stadium Mall Dirve West Lafayette IN 47906 United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T.","family":"Miller","sequence":"additional","affiliation":[{"name":"Davidson School of Chemical Engineering Purdue University  480 Stadium Mall Dirve West Lafayette IN 47906 United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radek","family":"Zboril","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute Palack\u00fd University  Olomouc 27 \u0160lechtitel\u016f 779 00 Czech Republic"},{"name":"Nanotechnology Centre Centre for Energy and Environmental Technologies VSB\u2013Technical University of Ostrava  17. Listopadu 2172\/15 Ostrava\u2010Poruba 708 00 Czech\u00a0Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering Shandong University  Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-094X","authenticated-orcid":false,"given":"Manoj B.","family":"Gawande","sequence":"additional","affiliation":[{"name":"Department of Industrial and Engineering Chemistry Institute of Chemical Technology Mumbai\u2010 Marathwada Campus  Jalna Maharashtra 431213 India"},{"name":"Nanotechnology Centre Centre for Energy and Environmental Technologies VSB\u2013Technical University of Ostrava  17. 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