{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:08:10Z","timestamp":1784581690960,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322026 82402032"],"award-info":[{"award-number":["82322026 82402032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20240484730"],"award-info":[{"award-number":["20240484730"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["5254026"],"award-info":[{"award-number":["5254026"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1803002"],"award-info":[{"award-number":["2024YFA1803002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1802200"],"award-info":[{"award-number":["2024YFA1802200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA0805701"],"award-info":[{"award-number":["2021YFA0805701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1104300"],"award-info":[{"award-number":["2022YFA1104300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1103100"],"award-info":[{"award-number":["2022YFA1103100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mammalian placental metabolism is crucial for both placental and embryonic development. However, the metabolic profiles of placentas and their regulatory roles in placentogenesis and embryonic development at different developmental stages remain poorly characterized. To address these questions, we collect 501 mouse placentas spanning embryonic day (E) 8.5\u201314.5 and construct metabolomic\u2013transcriptomic atlases of placentogenesis. Metabolomic and transcriptomic analyses reveal that placental samples from E8.5 to E14.5 are clustered into three separated states: E8.5, E9.5\u201310.5, and E11.5\u201314.5, pinpointing the metabolic transitions during placentogenesis from E8.5 to E9.5 and from E10.5 to E11.5. Based on a series of metabolite and enrichment analyses, Nicotinamide adenine dinucleotide (NAD(H)), flavin adenine dinucleotide (FAD), and L\u2010glutamate (Glu) are identified as differentially abundant metabolites (DAMs) during E8.5\u201314.5. Using in vitro cultured (IVC) embryos, NAD(H) is shown to promote the extension of embryonic body length, through accelerated segmentation and increased proliferation, as verified in NAD(H)\u2010treated mouse embryonic stem cell (mESC)\u2010induced presomitic mesoderm (PSM)\u2010like progenitor cells. These findings not only serve as an invaluable resource for understanding placental metabolism and its contribution to embryogenesis but also shed light on the mechanisms underlying developmental abnormalities associated with placental metabolic dysfunction.<\/jats:p>","DOI":"10.1002\/advs.202507928","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:11:17Z","timestamp":1769595077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development"],"prefix":"10.1002","volume":"13","author":[{"given":"Gang","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichen","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyi","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wu","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center the First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan P. R. China"},{"name":"Henan Key Laboratory of Reproduction and Genetics the First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dainan","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwu","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-4785","authenticated-orcid":false,"given":"Hongmei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ng","family":"Shyh\u2010Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglei","family":"Zhai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Institute of Molecular Medicine College of Future Technology Peking University  Beijing China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.08.029"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioz201"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01602"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj3725"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20100933\u20109"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010022\u201000513\u2010z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00570"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.183939"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.126474"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/01926233211042270"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60266"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00001.2005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201077360\u20101_10"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00001.2005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201003530\u20106"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09972"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201006938\u20104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00132.2014"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00291"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.574034"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.08.012"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004557\u20109"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010025\u201001720\u2010y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00\u20100566fje"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706204200"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11060880"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.018"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgae207"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioab165"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.09.042"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioac126"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy129"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.042"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005527\u2010x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005574\u20104"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1030514"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056120\u20105"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genet\u2010022123\u2010104503"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000709\u2010z"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091313"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005574\u20104"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.777844"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.09.013"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2023.01.007"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","unstructured":"M.Parenti S.Rosen M.Pettes et\u00a0al. \u201cMulti\u2010omic Integration Reveals Dynamic Changes in Human Placental Metabolism Across Gestation \u201dbioRxiv(2025) https:\/\/doi.org\/10.1101\/2025.10.22.683996.","DOI":"10.1101\/2025.10.22.683996"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051496"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.07.002"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.06.014"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202302505"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20100169"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70061"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101456"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055589\u2010w"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1226603"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010023\u201002014\u20107"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101885\u20109"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202507928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202507928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202507928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:19:46Z","timestamp":1775125186000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202507928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":57,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/advs.202507928"],"URL":"https:\/\/doi.org\/10.1002\/advs.202507928","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2025-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e07928"}}