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Selected formulations encompassing lipid nanoparticles and polymeric nanoparticles have already attained regulatory approval for clinical treatment. Nonetheless, achieving precise spatiotemporal control of exogenous nanomedicine within intricate physiological environments remains a formidable challenge. Drawing inspiration from evolutionarily optimized natural biological architectures, the development of biomembrane\u2010derived nanostructures with unique biological activities provides a new impetus for designing personalized antitumor drugs. Biomembrane\u2010derived constituents, particularly cell membrane, extracellular vesicles, and other bioactive payloads, have inherited their precise targeting, specific tumor killing, and dynamic tumor immunosuppressive microenvironments remodeling properties in antitumor intervention. Here, the diverse biomembrane engineering strategies to equip the biomembrane with plentiful functionalities are highlighted. 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