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Wound healing is a pivotal process that is essential for the reconstruction of epithelial homeostasis following damage to mucous membrane. However, the endogenous metabolites capable of expediting intestinal mucosal healing remain largely undefined. The aim of this study is to identify a pro\u2010repair metabolite to accelerate colonic wound healing. The investigation reveals that the serum levels of 7\u2010ketodeoxycholic acid (7\u2010KDCA), deoxycholic acid (DCA), and lithocholic acid (LCA) are depleted in patients with UC and colitic mice relative to controls. Among the three bile acids, 7\u2010KDCA exhibits the most conspicuous, which is correlated with disease severity. 7\u2010KDCA treatment exerts the strongest promotion of mucosal healing in mice with dextran sulfate sodium\u2010induced mucosal damage or biopsy\u2010induced colonic wounding injury. Mechanistically, 7\u2010KDCA functions by driving intestinal epithelial cell migration through induction of calcium release from the endoplasmic reticulum via targeting the TGR5\u2010IP3R axis. Amidst the array of endogenous metabolites potentially active in progression of UC, 7\u2010KDCA stands out as the preeminent facilitator in the healing of colonic mucosa. This finding may hold clinical significance for treating mucosal defect\u2010related diseases, including UC.<\/jats:p>","DOI":"10.1002\/advs.202507953","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:37:09Z","timestamp":1757921829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["7\u2010Ketodeoxycholic Acid Promotes Colonic Mucosal Healing by Inducing Calcium Release from Endoplasmic Reticulum via the TGR5\u2010IP3R Pathway"],"prefix":"10.1002","volume":"12","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy School of Traditional Chinese Pharmacy China Pharmaceutical University  Nanjing 211198 P. R. 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