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Herein, the concept of holding desired dual\u2010site nanozymes is proposed through developing Fe\u2500Fe dimers on nitrogen\u2010doped porous carbon (Fe\n                    <jats:sub>2<\/jats:sub>\n                    \u2010NCs) to eliminate excessive ROS through the co\u2010adsorption mechanism of superoxide radical. The Fe\n                    <jats:sub>2<\/jats:sub>\n                    \u2010NCs present an enhanced ROS performance, effectively mimicking key antioxidant enzymes. Density functional theory calculations indicate that the synergistic effects of the Fe\u2500Fe dimer can modulate oxygen adsorption configurations and accelerating O\u2500O bond\u2010cleavage. In vitro and in vivo results show that Fe\n                    <jats:sub>2<\/jats:sub>\n                    \u2010NCs effectively mitigate ROS, protecting chondrocytes from oxidative stress\u2010induced apoptosis. The mitochondrial function can be strengthened over Fe\n                    <jats:sub>2<\/jats:sub>\n                    \u2010NCs by inhibiting NOX4 expression, restoring ATP levels, and normalizing COXIV expression. Additionally, Fe\n                    <jats:sub>2<\/jats:sub>\n                    \u2010NCs significantly downregulate the pro\u2010inflammatory mediator COX\u20102, inhibit MMP\u201013\u2010mediated cartilage degradation, and slow down the type II collagen (COL2) breakdown through the inhibition of NF\u2010\u03baB signaling pathway.\n                  <\/jats:p>","DOI":"10.1002\/advs.202508073","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:52:19Z","timestamp":1760971939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Constructing Dual\u2010Atomic Fe\u2500Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Ting","family":"Ying","sequence":"first","affiliation":[{"name":"Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation 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