{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:00:15Z","timestamp":1790254815842,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2018YFA0704104"],"award-info":[{"award-number":["2018YFA0704104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2018YFA0704100"],"award-info":[{"award-number":["2018YFA0704100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2018YFA0704103"],"award-info":[{"award-number":["2018YFA0704103"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Integrating mild hyperthermia (MH) with\n                    <jats:sup>125<\/jats:sup>\n                    I brachytherapy holds potential for overcoming treatment resistance and improving anticancer efficacy. Here, magnetic nanoparticles (MNPs) with a suitable Curie temperature are constructed and incorporated with silver rods coated with\n                    <jats:sup>125<\/jats:sup>\n                    I to form composite seeds. In vitro simulations and in vivo validations demonstrated their effective performance in radiation dose and temperature control. Compared with traditional thermoseeds and previously reported MNPs, this composite seed exhibits direction\u2010independent and self\u2010regulated heating efficiency. Additionally, the titanium shell prevented MNPs leakage and enabled its repeated hyperthermia treatment capacity. Subsequently, the enhanced pancancer anticancer efficacy of the composite seed\u2010relied\n                    <jats:sup>125<\/jats:sup>\n                    I@MH therapy is confirmed through cellular and animal experiments involving liver cancer and prostate cancer. Further tumor microenvironment investigations based on a subcutaneous liver cancer mouse model identified that\n                    <jats:sup>125<\/jats:sup>\n                    I therapy recruited Cd274\/Pd\u2010l1\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils and induced T\u2010cell exhaustion, leading to immune evasion and brachytherapy resistance. The addition of MH significantly reversed this effect, restoring the function of effector T cells (IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T cells) and activating T\u2010cell immunity. In conclusion, this study developed a novel composite seed with superior anticancer efficacy, which holds promising therapeutic potential for the treatment of malignancies, particularly solid tumors, in future clinical practice.\n                  <\/jats:p>","DOI":"10.1002\/advs.202508091","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:06:24Z","timestamp":1756458384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Novel Self\u2010Regulated, Non\u2010Directional Magnetic Thermos\u2010Brachytherapy\n                    <sup>125<\/sup>\n                    I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-0500","authenticated-orcid":false,"given":"Bin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Urology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u2010Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Fei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Oncology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai\u2010Wen","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology  Dalian 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Rong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin\u2010Da","family":"Chen","sequence":"additional","affiliation":[{"name":"JACO PHARMACEUTICALS CO., LTD  NingBo 315800 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u2010Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology  Dalian 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Pu","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Cheng","family":"Jin","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En\u2010Qi","family":"Qiao","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ze","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Intelligent Medical Image Computing School of Future Technology Nanjing University of Information Science and Technology  Nanjing 210044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology  Dalian 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology  Dalian 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Bing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Oncology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Lu","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao\u2010Jun","family":"Teng","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology and Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University  Nanjing 210009 China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University) State Key Laboratory of Digital Medical Engineering Southeast University  Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.09.002"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-01682-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3958"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0246-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121801"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-995476"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24666"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.096"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15051394"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/0265673031000119006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901058"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.05.062"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.05.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2010.487194"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.11.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.4996"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.038"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00819"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122514"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2020.154724"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmmm.2024.171724"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-844548"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13176"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1821"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.038"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.02.006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade2292"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.05.004"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11090900"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-017-0813-0"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmmm.2019.165382"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313075"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2312855121"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03122-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05400-x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-002305"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.02.009"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00336-7"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.10.008"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-005619"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.01.008"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4994309"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-012-0974-6"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMAG.2015.2512439"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmmm.2016.04.095"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2010.06.007"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.1.5"},{"key":"e_1_2_9_48_1","unstructured":"C.Baumgartner P. A.Hasgall F.Di Gennaro E.Neufeld B.Lloyd M. C.Gosselin D.Payne A.Klingenb\u00f6ck N.Kuster \u201cIT'IS Database for thermal and electromagnetic parameters of biological tissues \u201d Version 5.0 August 21 2025. itis.swiss\/database."},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781315380476"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2020.102644"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.74.877.740056"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03950-0"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202508091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:03:14Z","timestamp":1790251394000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202508091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":55,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/advs.202508091"],"URL":"https:\/\/doi.org\/10.1002\/advs.202508091","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e08091"}}