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Oral exposure through food is a significant route of human contact with nanoparticles; however, the potential risk of AD induced by food\u2010grade nanoparticles and the underlying mechanisms remain largely unclear. Here, this study reveals a common mechanism by which food\u2010grade nanoparticles, including titanium dioxide, nanosilica, and nanosilver, trigger AD\u2010like pathological changes through epigenetic alterations. Exposure to food\u2010grade nanoparticles triggers changes in DNA methylation and aberrant ryanodine receptor\u2010Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling in the mouse brain, contributing to lysosomal impairment and disrupted autophagic flux in neurons. Crucially, these autophagy defects reduced the ability to clear \u03b2\u2010amyloid and pTau proteins, which ultimately accumulated and triggered spatial cognition and memory deficits in mice. In conclusion, this study elucidates the shared toxicological mechanisms induced by different food\u2010grade nanoparticles, thereby offering valuable insights into ingested nanoparticle exposure and its potential association with neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.202508096","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:26:37Z","timestamp":1761657997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral Exposure to Food\u2010Grade Nanoparticles Poses a Risk of Alzheimer's Disease\u2010Like Symptoms by Triggering Autophagy Defects in Neurons"],"prefix":"10.1002","volume":"13","author":[{"given":"Jiaxin","family":"Shang","sequence":"first","affiliation":[{"name":"Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences Zhejiang University  Hangzhou 310058 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