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The novel integrin \u03b1v\u03b26\u2010targeted radiotracer [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga\u2010Trivehexin shows excellent targeting specificity and favorable tumor\u2010to\u2010background contrast. In this prospective clinical study (NCT05835570) involving 58 participants with non\u2010small cell lung cancer (NSCLC), [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga\u2010Trivehexin and 2\u2010deoxy\u20102\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoro\u2010\n                    <jats:italic>D<\/jats:italic>\n                    \u2010glucose ([\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG) positron emission tomography\/computed tomography (PET\/CT) showed perfect diagnostic accuracy (100%, 58\/58) for the detection of primary tumors. In detecting lymph node metastasis, [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga\u2010Trivehexin exhibited similar diagnostic sensitivity to [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG PET\/CT (80.0% vs 72.0%), with higher specificity (93.8% vs 62.5%,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.001) and accuracy (91.2% vs 64.2%,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.001) in per\u2010station analysis. [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga\u2010Trivehexin outperformed [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG in detecting brain metastasis (sensitivity, 92.3% vs 38.5%;\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.031). Additionally, [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga\u2010Trivehexin PET\/CT results changed the therapeutic regimens of 14 (24.1%) participants. The maximum standardized uptake value (SUVmax) and tumor\u2010to\u2010liver parenchyma ratio (TLR) derived from [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga\u2010Trivehexin correlated with integrin \u03b26 expression in NSCLC. Overall, [\n                    <jats:sup>68<\/jats:sup>\n                    Ga]Ga\u2010Trivehexin PET\/CT represents an invaluable tool for identifying lymph node and brain metastases and shows comparable diagnostic efficacy in detecting primary tumors and other distant metastases compared with [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG in NSCLC, potentially guiding treatment decision\u2010making.\n                  <\/jats:p>","DOI":"10.1002\/advs.202508225","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:06:28Z","timestamp":1756897588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Integrin \u03b1v\u03b26\u2010Targeted PET\/CT Imaging of Non\u2010Small Cell Lung Cancer with [\n                    <sup>68<\/sup>\n                    Ga]Ga\u2010Trivehexin: Improved Preoperative Lymph Node Staging and Association with Immunohistochemistry"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4473-6936","authenticated-orcid":false,"given":"Huiqin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Zhongnan Hospital of Wuhan University  No. 169 East Lake Road, Wuchang District Wuhan Hubei Province 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongjiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Zhongnan Hospital of Wuhan University  No. 169 East Lake Road, Wuchang District Wuhan Hubei Province 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Zhongnan Hospital of Wuhan University  No. 169 East Lake Road, Wuchang District Wuhan Hubei Province 430071 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