{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:44:57Z","timestamp":1791434697105,"version":"4.3.3"},"reference-count":88,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R56EB032395"],"award-info":[{"award-number":["R56EB032395"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Noncompressible hemorrhage is a leading cause of death in both combat and lay settings, primarily due to the challenges in accessing and treating injuries deep within abdominal tissues where traditional compression\u2010based methods are ineffective. Existing hemostatic materials fail to address the needs of large wound cavities, necessitating the development of advanced materials with rapid expansion and superior hemostatic properties. Here we report an expandable hemostat engineered from a nanocomposite\u2010coated shape memory foam. This material exhibits rapid expansion, achieving a ~5X increase in volume within 3 min in vitro, and demonstrates notable shape recovery in vivo. The material's hemostatic efficacy is evident through a ~70% reduction in clotting time compared to untreated controls, primarily due to the ability to adhere platelets and red blood cells. Moreover, the composite material displays excellent hemocompatibility and cytocompatibility, with low hemolysis rates and high cellular viability. In vivo assessments further confirm its effectiveness, showing an accelerated clotting time (~80% reduction) and decreased blood loss (~50% decrease), alongside minimal inflammation and necrosis in histological analyses. Additionally, the composite demonstrates good biocompatibility following subcutaneous implantation, illustrating its efficacy in vivo. Overall, the synergistic effect of rapid expansion by shape memory foam, along with the excellent procoagulant ability of the nanocomposite makes this biocompatible, expandable hemostat a promising treatment for noncompressible hemorrhage.<\/jats:p>","DOI":"10.1002\/advs.202508439","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T08:18:31Z","timestamp":1770365911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Expandable Nanocomposite Shape\u2010Memory Hemostat for the Treatment of Noncompressible Hemorrhage"],"prefix":"10.1002","volume":"13","author":[{"given":"Saptarshi","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9698-6956","authenticated-orcid":false,"given":"Shounak","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeevika","family":"Thazhaiselvam","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences College Station Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Foster","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Genetics College Station Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manivannan Sivaperuman","family":"Kalairaj","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha M.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Material Science and Engineering College of Engineering College Station Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yava","family":"Jones\u2010Hall","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences College Station Texas A&amp;M University  College Station Texas USA"},{"name":"Department of Veterinary Pathobiology College Station Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staci J.","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred J.","family":"Clubb","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences College Station Texas A&amp;M University  College Station Texas USA"},{"name":"Department of Veterinary Pathobiology College Station Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor H.","family":"Ware","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering Texas A&amp;M University  College Station Texas USA"},{"name":"Department of Material Science and Engineering College of Engineering College Station Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan J.","family":"Maitland","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0284-0201","authenticated-orcid":false,"given":"Akhilesh K.","family":"Gaharwar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering Texas A&amp;M University  College Station Texas USA"},{"name":"Interdisciplinary Program in Genetics College Station Texas A&amp;M University  College Station Texas USA"},{"name":"Department of Material Science and Engineering College of Engineering College Station Texas A&amp;M University  College Station Texas USA"},{"name":"Center For Remote Health Technologies and Systems College Station Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba0588"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700859"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308701"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00170"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202004153"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202305222"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121432"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121546"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-020-00241-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c01015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjtee.2021.03.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318299da0a"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000646"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/b139006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.55460\/T63H\u20103OXX"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202102583"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205989"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c02144"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00798"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.06.019"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010011\u20100468\u20101"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34337"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.09.027"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36901"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.10.005"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34732"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202521053"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/polb.23982"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.110263"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049\u2010016\u20100301\u20109"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.12.014"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.126329"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182617c3c"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129815"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129136"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/polb.23056"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.201701015"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1088\/0964\u20101726\/20\/8\/085010"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311684"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.10.008"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado1223"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clay.2010.01.007"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201502422"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900332"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.04.014"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c02030"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00781A"},{"issue":"1","key":"e_1_2_9_49_1","article-title":"Gelatin Based Scaffolds for Tissue Engineering\u2014A Review","volume":"9","author":"Hoque M. E.","year":"2015","journal-title":"Polymers Research Journal"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3184803"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.01.045"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202400321"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.06.030"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109797(92)90254\u2010J"},{"key":"e_1_2_9_55_1","volume-title":"Infrared and Raman Characteristic Group Frequencies: Tables and Charts","author":"Socrates G.","year":"2004"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.08.108"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1557\/adv.2019.441"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2005.12.002"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.47857"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah5533"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.07.043"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1448"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM01351C"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2959414"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.03.094"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004998\u20109"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34782"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9060143"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.7"},{"key":"e_1_2_9_70_1","volume-title":"Standard Practice for Assessment of Hemolytic Properties of Materials","author":"ASTM F0756\u201017","year":"2024"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.10.084"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB01085D"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b01364"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20108977\u201010\u201041"},{"key":"e_1_2_9_75_1","volume-title":"Wound Closure Biomaterials and Devices","author":"Chu C.\u2010C.","year":"1996"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.04.043"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.47268"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3sm27352k"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA03731J"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12182\u2010018\u20100298\u2010y"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.140554"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100918"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b04615"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.03.016"},{"key":"e_1_2_9_85_1","article-title":"Isolation of human Platelets From Whole Blood","author":"Abcam","year":"2019","journal-title":"Abcam"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213182"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c11155"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024972\u20102"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.4c00336"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202508439","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:25:58Z","timestamp":1776939958000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202508439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":88,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/advs.202508439"],"URL":"https:\/\/doi.org\/10.1002\/advs.202508439","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"2025-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e08439"}}