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While major histocompatibility complex (MHC)\u2010dependent B cell activation and thyroid\u2010stimulating hormone receptor (TSHR) autoantibody production are central to GD, the intrathyroidal immune landscape remains largely unexplored. Through single\u2010cell RNA sequencing (scRNA\u2010seq), this work constructed a comprehensive immune cell atlas, revealing dominant IFN\u2010\u03b3\u2010secreting CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, expanded T peripheral helper (Tph) cells, CD11c\n                    <jats:sup>+<\/jats:sup>\n                    atypical B cells, and CD8\n                    <jats:sup>+<\/jats:sup>\n                    effector T cells. Notably, stress\u2010surveilling \u03b3\u03b4 T\/NK cells are enriched in GD. Thyroid follicular cells (TFCs) in GD exhibited a stressed phenotype, and in vitro functional assays showed that they promote \u03b3\u03b4 T cell activation and proliferation. \u03b3\u03b4 T cells may recruit conventional type 1 dendritic cells (cDC1) via XCL1\/XCL2, suggesting a potential link to adaptive immune reorganization. These findings suggest an additional MHC\u2010independent pathway linking TFC stress to autoimmune activation via \u03b3\u03b4 T cells in GD pathogenesis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202508449","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:26:50Z","timestamp":1761215210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single\u2010Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaoyi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine (SJTUSM) Shanghai 200023 China"},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic 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