{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:23:51Z","timestamp":1786976631087,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301710"],"award-info":[{"award-number":["82301710"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gut microbiota may play a role in regulating the stress hormone cortisol. However, the mechanisms underlying the regulation of cortisol by gut microbiota are poorly understood. Here, it is found that gut microbiota degraded cortisol, and this ability is heterogeneous among individuals. Mice gavaged with gut microbiota having a low ability to degrade cortisol may be prone to developing depressive\u2010like behavior. The cortisol\u2010degrading strain Pseudomonas aeruginosa Tongji is isolated from faecal microbiota. The des\u2010like enzyme expressed by P. aeruginosa Tongji converts cortisol into androgen. Bacterial des\u2010like enzyme protects mice against depressive\u2010like behavior via degrading cortisol and producing androgen. The probiotic Bacillus subtilis expressing the des\u2010like enzyme is constructed, which protects the host against cortisol elevation. These findings suggest that bacterial des\u2010like enzyme may regulate cortisol and improve depression by converting cortisol into androgen.<\/jats:p>","DOI":"10.1002\/advs.202508468","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:52:26Z","timestamp":1767873146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine institute of translational medicine, Renmin Hospital of Wuhan University Wuhan Hubei 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Long","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Renmin Hospital of Wuhan University, Taikang Center for Life and Medical Sciences, State Key Laboratory of Metabolism and Regulation in Complex Organisms, Wuhan University Wuhan Hubei 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Biliary\u2010Pancreatic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Zhao","family":"Xie","sequence":"additional","affiliation":[{"name":"Precision Medical Center Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital) Tongji Medical College Huazhong University of Science and Technology Wuhan 430015 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u2010Wei","family":"Ye","sequence":"additional","affiliation":[{"name":"Cancer Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Yong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Renmin Hospital of Wuhan University, Taikang Center for Life and Medical Sciences, State Key Laboratory of Metabolism and Regulation in Complex Organisms, Wuhan University Wuhan Hubei 430060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ming","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5170-6823","authenticated-orcid":false,"given":"Di","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Tongji Hospital Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Huazhong University of Science and Technology  Wuhan Hubei 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-07015-2"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.8.789"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-062520-122331"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12232726"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.12.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110601"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00260-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03669-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8735"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.63.1006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.77"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.01.014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-021-00492-5"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000125248"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23112832"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.02.017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114978"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2109.2008.02135.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1782"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6941.12301"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1019"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2201155"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02590"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000102"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2015.00032"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules181113228"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0336-x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091021"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.81067"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06111-7"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad031"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043081"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00159-7"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2023.1817"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.020"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.3620330115"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5384-x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10030508"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad766"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0061-2"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.112072"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1203502"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5039.272"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-19-4-444"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(87)90123-3"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M038869"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105567"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M083949"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M074914"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8844"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.580980"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2025.1564994"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2023.12.006"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2023-0118"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioflm.2023.100128"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2023.106124"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2013.09.001"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1979878"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.01.001"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0814s24"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1118"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202508468","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:28:46Z","timestamp":1772958526000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202508468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/advs.202508468"],"URL":"https:\/\/doi.org\/10.1002\/advs.202508468","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e08468"}}