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Cold exposure is a WAT browning\u2010inducing condition in mice. Hypothalamus regulates WAT browning. However, the mechanism of central regulation of WAT browning is still elusive. Here, it is reported that GABAergic neurons in the dorsomedial hypothalamus (DMH\n                    <jats:sup>GABA<\/jats:sup>\n                    neurons) are activated in response to cold exposure. Designer receptors exclusively activated by designer drugs (DREADDs) activation of DMH\n                    <jats:sup>GABA<\/jats:sup>\n                    neurons elicited WAT browning, increased energy expenditure, lowered fat mass weights, and body weight. Conversely, inactivation of DMH\n                    <jats:sup>GABA<\/jats:sup>\n                    neurons showed the opposite effects. Cell type\u2010specific anterograde tracing revealed that DMH\n                    <jats:sup>GABA<\/jats:sup>\n                    neurons projected to the lateral preoptic area (LPO). Chemogenetic and optogenetic functional circuit interrogation demonstrated that the activation of this projection induced WAT browning. Together, it is uncovered that DMH\n                    <jats:sup>GABA<\/jats:sup>\n                    neurons may act as a key neuronal population controlling cold exposure\u2010induced WAT browning. DMH\n                    <jats:sup>GABA<\/jats:sup>\n                    neurons regulate WAT browning through DMH to LPO projection. This study expands the understanding of the central mechanism governing the white adipose browning, as well as the anti\u2010obesity effects of cold therapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202508513","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:39:09Z","timestamp":1762349949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The DMH\n                    <sup>GABA<\/sup>\n                    Neurons Play a Crucial Role in the Regulation of Cold\u2010Induced White Adipose Browning through DMH to LPO Projection"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhijie","family":"Su","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology and Embryology School of Basic Medical Sciences Peking University  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology School of Basic Medical Sciences Peking University  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Basic Medicine Research Innovation Center for Cardiometabolic Diseases Ministry of Education Southwest Medical University  Luzhou 646000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology &amp; 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