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These devices integrate semi\u2010biological components such as synthetic membranes with organic electronics. For instance, Supported Lipid Bilayers (SLBs) offer a promising substrate as biomimetic membranes, by providing a stable and controlled interface for bioelectronic and biomimetic applications. However, challenges remain in SLB formation, particularly in achieving consistent transmembrane ionic resistance due to packing defects. This work reports a framework of the dielectric properties of a SLB dielectric stack, and investigates the impact of defects on the membrane resistance variations. According to the model, lipid packing non\u2010idealities lead to the partial hydration of the inner part of the membrane and thus to transmembrane resistance variations. These findings offer new insights into the dielectric and transmembrane barrier characteristics of SLBs by introducing a quantitative assessment method that transcends qualitative experimental observations, paving the way for a systematic approach to designing controllable membranes and biointerfaces with customizable biomimetic properties.<\/jats:p>","DOI":"10.1002\/advs.202508589","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:23:33Z","timestamp":1762838613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Methodology for Deciphering the Transmembrane Resistance Variability of Supported Lipid Bilayers"],"prefix":"10.1002","volume":"13","author":[{"given":"Aristea","family":"Pavlou","sequence":"first","affiliation":[{"name":"Max Planck Institute for Polymer Research  Ackermannweg 10 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debdatta","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research  Ackermannweg 10 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Kashani","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering North Carolina State University  890 Oval Dr Raleigh NC 27606 USA"},{"name":"Carbon Electronics Laboratories (ORaCEL) North Carolina State University  Raleigh NC 27695 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Maria","family":"Pappa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Biotechnology Khalifa University  Abu Dhabi PO Box 127788 UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Torricelli","sequence":"additional","affiliation":[{"name":"Department of Information Engineering University of Brescia  via Branze 38 Brescia 25123 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.M.","family":"Blom","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research  Ackermannweg 10 55128 Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-0851","authenticated-orcid":false,"given":"Paschalis","family":"Gkoupidenis","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Polymer Research  Ackermannweg 10 55128 Mainz Germany"},{"name":"Department of Electrical and Computer Engineering North Carolina State University  890 Oval Dr Raleigh NC 27606 USA"},{"name":"Carbon Electronics Laboratories (ORaCEL) North Carolina State University  Raleigh NC 27695 USA"},{"name":"Department of Physics North Carolina State University  2401 Stinson Dr Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00539"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm4022003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00026"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202102039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2494"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax0729"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2573"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf6121"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48881-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0435-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2217\/bem-2019-0014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0079011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0127-y"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-024-00180-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1557\/mrc.2020.56"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-023-00622-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2020.100546"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.41735"},{"key":"e_1_2_9_19_1","first-page":"2024","volume":"11","author":"Lu Z.","year":"2024","journal-title":"Adv. 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