{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:38:54Z","timestamp":1790786334854,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400882"],"award-info":[{"award-number":["82400882"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370746"],"award-info":[{"award-number":["82370746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170762"],"award-info":[{"award-number":["82170762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M753763"],"award-info":[{"award-number":["2024M753763"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750592"],"award-info":[{"award-number":["2024M750592"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012637"],"award-info":[{"award-number":["2022A1515012637"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peritoneal dialysis (PD), as a renal replacement therapy, relies heavily on the structural and functional integrity of the peritoneum. In some patients, however, the peritoneum may undergo adverse remodeling and fibrotic thickening, resulting in treatment failure. Here, a previously unrecognized metabolic\u2010epigenetic mechanism contributing to peritoneal fibrogenesis is uncovered, wherein lactate accumulation in injured peritoneal mesothelial cells promotes histone H3K18 lactylation and transcriptional activation of macrophage\u2010recruiting chemokine CCL2. In a mouse model of peritoneal fibrosis induced by chlorhexidine gluconate (CG) or PD fluid, the administration of extracellular vesicles derived from human bone marrow mesenchymal stem cells (MSC\u2010EVs) significantly ameliorates histological and functional changes in the peritoneum. Single\u2010cell RNA sequencing reveals that MSC\u2010EVs attenuate mesothelial\u2010macrophage crosstalk by suppressing CCL2 signaling. Mechanistically, MSC\u2010EVs reprogram glycolytic metabolism in mesothelial cells, reduce lactate production, and inhibit H3K18 lactylation\u2010dependent transcriptional activation of CCL2. Pharmacologic blockade of lactate production recapitulates the protective effects of MSC\u2010EVs. These findings suggest that lactate\u2010induced histone lactylation is a key driver of peritoneal fibrosis, positioning MSC\u2010EVs as a promising cell\u2010free therapeutic strategy for targeting metabolic\u2010epigenetic inflammation in serosal injury.<\/jats:p>","DOI":"10.1002\/advs.202508645","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:20:26Z","timestamp":1764156026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mesenchymal Stem Cell\u2010Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-1140","authenticated-orcid":false,"given":"Qiang","family":"Huang","sequence":"first","affiliation":[{"name":"Nephrology Division Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengpeng","family":"Kuang","sequence":"additional","affiliation":[{"name":"Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Southern Medical University Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sun","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Guo","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinrong","family":"Song","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Huo","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canming","family":"Li","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Witowski","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Poznan University of Medical Sciences Poznan 61\u2010701 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyong","family":"Hu","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine Baylor College of Medicine Houston 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0220-3616","authenticated-orcid":false,"given":"Hui","family":"Peng","sequence":"additional","affiliation":[{"name":"Nephrology Division Department of Medicine The Third Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4942"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00623-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.03.040"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168607"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.99"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319310"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03849-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.07.011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01037-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12495"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00248"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12497"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2022.0244"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0040-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.05.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000762"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav5341"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0074-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01055-2"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1678-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.04.006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07620-9"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.07.018"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.06.013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02162-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V13112787"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2020.1723260"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.131273"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.022"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-025-02113-2"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00883.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103246"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01985-9"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12334"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202508645","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:58:03Z","timestamp":1769687883000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202508645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/advs.202508645"],"URL":"https:\/\/doi.org\/10.1002\/advs.202508645","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"2025-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e08645"}}