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To address this, a hypothesis generating multi\u2010agent AI system (AI co\u2010scientist) is used to assist in re\u2010purposing drugs for treatment of liver fibrosis and direct their experimental characterization. The anti\u2010fibrotic efficacy and toxicity of 25 drugs are serially assessed in multi\u2010lineage human hepatic organoids grown in microwells (i.e., microHOs). Remarkably, three previously characterized anti\u2010fibrotic drugs and two AI co\u2010scientist\u2010recommended drugs that targeted epigenomic modifiers exhibited significant anti\u2010fibrotic activity and they promoted liver regeneration. Analysis of these five anti\u2010fibrotic drugs revealed that they all can reduce the generation of activated myofibroblasts and that each drug have unique effects on mesenchymal cells that generated their anti\u2010fibrotic effects. 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