{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T11:41:50Z","timestamp":1773574910389,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300986"],"award-info":[{"award-number":["82300986"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470924"],"award-info":[{"award-number":["82470924"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2024ZD0530400"],"award-info":[{"award-number":["2024ZD0530400"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    X\u2010linked hypophosphatemic rickets (XLHR) is a rare X\u2010linked dominant skeletal dysplasia caused by phosphate regulating endopeptidase homolog X\u2010linked (PHEX) gene mutation. Until now, the pathogenic role of PHEX has not been fully determined, and there has been no radical cure for XLHR. In the previous study, a novel\n                    <jats:italic>PHEX<\/jats:italic>\n                    variant (c.T1349C; p.L450P) is identified in a child with XLHR. The present study aims to reveal its pathogenic role and evaluate the therapeutic effects of the minicircle (MC)\u2010DNA in XLHR. In vitro, the wildtype and mutant plasmids are introduced into HEK293 cells. In vivo, a new knock\u2010in XLHR mouse model carrying the novel variant is established. Furthermore, this study makes the first attempt to perform gene therapy using a MC\u2010DNA vector expressing a fragment of FGF23 (amino acids 180\u2010251) in the\n                    <jats:italic>Phex<\/jats:italic>\n                    \u2010T1349C mice. The new mouse model demonstrates the clinical manifestations of XLHR seen in the patient, including a gene dosage effect. Furthermore, MC\u2010DNA is found to slightly increase blood phosphorus levels, significantly decrease serum alkaline phosphatase levels, and improve bone mineralization without apparent adverse effects for at least 6 weeks. This study suggests MC\u2010DNA as a promisingly safe and effective therapeutic strategy to treat XLHR.\n                  <\/jats:p>","DOI":"10.1002\/advs.202508870","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T20:14:31Z","timestamp":1761941671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X\u2010Linked Hypophosphatemic Rickets"],"prefix":"10.1002","volume":"13","author":[{"given":"Huixiao","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Shandong Provincial Research Center for Stem Cells and Gene Therapy of Endocrine Metabolic Diseases  Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuoshuo","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzhou","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Shandong Provincial Research Center for Stem Cells and Gene Therapy of Endocrine Metabolic Diseases  Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongyue","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Shandong Provincial Research Center for Stem Cells and Gene Therapy of Endocrine Metabolic Diseases  Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renyuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology Shandong Rongjun General Hospital  Jinan 250013 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Shu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical imaging Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Syno Minicircle Biotechnology Co. Ltd.  Shenzhen 518107 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Syno Minicircle Biotechnology Co. Ltd.  Shenzhen 518107 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Laboratory Animals (Shandong Laboratory Animal Center) Medical Science and Technology Innovation Center Shandong Provincial Hospital Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan 250117 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibo","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing 100730 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Shandong Provincial Research Center for Stem Cells and Gene Therapy of Endocrine Metabolic Diseases  Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Shandong Provincial Research Center for Stem Cells and Gene Therapy of Endocrine Metabolic Diseases  Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Shandong Provincial Research Center for Stem Cells and Gene Therapy of Endocrine Metabolic Diseases  Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-8881","authenticated-orcid":false,"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology and Metabolism Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China"},{"name":"Shandong Provincial Research Center for Stem Cells and Gene Therapy of Endocrine Metabolic Diseases  Jinan 250021 P. R. China"},{"name":"Institute of Endocrinology Shandong Academy of Clinical Medicine  Jinan 250021 P. R. China"},{"name":"Shandong Clinical Medical Center of Endocrinology and Metabolism  Jinan 250021 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119276"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.15.1539"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021809"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.88.BJR-2018-0276.R1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00665-x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-021-00709-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1014-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301264"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.340"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13763"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714641"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31054-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30654-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3475"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac296"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30338-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1706910"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1815776"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0012-9"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-017-0234-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj5018"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.822389"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.658399"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2020.310"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-021-00608-7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtm.2014.62"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1426"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1708"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.249"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120072"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2016.37"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.014"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2016.122"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27104"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae120"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902006107"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.2.165"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64468-9"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-003-2310-z"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-007-9199-6"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-18-60"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24115"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114590"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080417"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.01.017"},{"key":"e_1_2_10_46_1","first-page":"4003","volume":"117","author":"Ben\u2010Dov I. Z.","year":"2007","journal-title":"J. Clin. Invest."},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1768"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.05.015"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81928"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.183"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900230"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00622-5"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.11.007"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801774200"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3597"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0143"},{"key":"e_1_2_10_57_1","first-page":"487","volume":"47","author":"Li H.","year":"2009","journal-title":"Zhonghua Erke Zazhi"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3550707"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2022.02.014"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202508870","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202508870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:00:49Z","timestamp":1769688049000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202508870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/advs.202508870"],"URL":"https:\/\/doi.org\/10.1002\/advs.202508870","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]},"assertion":[{"value":"2025-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e08870"}}