{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:17:20Z","timestamp":1791695840946,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"46","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["742401"],"award-info":[{"award-number":["742401"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/I011870"],"award-info":[{"award-number":["EP\/I011870"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/V056409"],"award-info":[{"award-number":["EP\/V056409"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The development of earth\u2010abundant metal\u2010based catalysts is an important goal for the synthesis of fine chemicals. Here, an active nickel catalyst supported on a robust metal\u2013organic framework, MFM\u2010300(Cr), is reported which shows an exceptional performance for reductive amination, a reaction that has long been dominated by noble metals. Ni\/MFM\u2010300(Cr) promotes the synthesis of 38 primary amines via reductive amination of their parent carbonyl compounds, including biomass\u2010derived aldehydes and ketones, using NH\n                    <jats:sub>3<\/jats:sub>\n                    in the presence of H\n                    <jats:sub>2<\/jats:sub>\n                    operating under relatively mild conditions (5\u00a0bar and 160\u00a0\u00b0C). X\u2010ray absorption spectroscopy confirms the formation of mixtures of metallic Ni\n                    <jats:sup>0<\/jats:sup>\n                    and Ni\n                    <jats:sup>n+<\/jats:sup>\n                    active sites, while in situ inelastic neutron scattering, coupled with modeling, reveals details of the mechanism of catalysis involving the formation of N\u2010benzyl\u20101\u2010phenylmethanediamine (BPDI) as an intermediate species in the generation of benzylamine. Cooperativity between Ni sites and MFM\u2010300(Cr) creates an optimal microenvironment for the efficient activation of carbonyl compounds and the selective production of primary amines using a non\u2010precious metal\u2010based catalyst.\n                  <\/jats:p>","DOI":"10.1002\/advs.202508892","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:48:13Z","timestamp":1761310093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis of Primary Amines via Reductive Amination of Aldehydes and Ketones Over a Ni\u2010Doped MFM\u2010300(Cr) Catalyst"],"prefix":"10.1002","volume":"12","author":[{"given":"Wenyuan","family":"Huang","sequence":"first","affiliation":[{"name":"College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Peking University  Beijing 100871 China"},{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"An","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinlin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangnan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Peking University  Beijing 100871 China"},{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"},{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Crawshaw","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Tillotson","sequence":"additional","affiliation":[{"name":"Department of Materials University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Materials University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Haigh","sequence":"additional","affiliation":[{"name":"Department of Materials University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M. A.","family":"Parlett","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering University of Manchester  Manchester M13 9PL UK"},{"name":"Diamond Light Source Harwell Science Campus  Oxfordshire OX11 0DE UK"},{"name":"UK Catalysis Hub Rutherford Appleton Laboratory  Oxfordshire OX11 0FA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Keenan","sequence":"additional","affiliation":[{"name":"Diamond Light Source Harwell Science Campus  Oxfordshire OX11 0DE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svemir","family":"Rudi\u0107","sequence":"additional","affiliation":[{"name":"ISIS Facility STFC Rutherford Appleton Laboratory  Oxfordshire OX11 0AF UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Neutron Scattering Division, Neutron Sciences Directorate Oak Ridge National Laboratory Oak Ridge TN TN 37830 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben F.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Materials University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6992-0700","authenticated-orcid":false,"given":"Martin","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihai","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Peking University  Beijing 100871 China"},{"name":"Department of Chemistry University of Manchester  Manchester M13 9PL UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6245"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610964"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-018-0202-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-020-00606-w"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08577-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC01084G"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13351-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23429-w"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b04481"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201812100"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b01113"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.8b06631"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b10107"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b12074"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19763"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0562-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcat.2012.05.015"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138748"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-020-0455-y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124985"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201703663"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23302-w"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-018-0033-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2738-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-019-0308-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01199-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nenergy.2016.186"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4EE01299B"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201510655"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja403330m"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41560-017-0078-8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201801896"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c05572"},{"key":"e_1_2_7_34_1","volume-title":"CrystalDiffract User's Guide","author":"Palmer D. 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