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Inspired by the framework\u2010reinforced composite structure of concrete in building construction, herein, a 3D\u2010printed polymeric framework reinforced zwitterionic lubricating hydrogel (abbreviated as 3DF\u2010LH) is developed, which features high tensile strength internally and optimal lubrication externally. Just like the establishment process of concrete, 3DF\u2010LH is fabricated by infiltrating hydrogel precursor solution, that consisted of GelMA and zwitterionic sulfobetaine methacrylate (SBMA), into the pores of a 3D\u2010printed PCL framework (3DF), followed by UV curing. In vitro studies demonstrated that the 3DF\u2010LH composite exhibited superior structural stability, mechanical robustness, and biocompatibility, along with significantly suppressing fibroblast adhesion. In an SD rat cecal\u2010abdominal wall postoperative adhesion model, 3DF\u2010LH attenuated the inflammatory microenvironment, which involved the suppression of the TGF\u2010\u03b2\/Smad signaling pathway, thereby effectively inhibiting abdominal adhesion formation. These findings demonstrate that developed 3DF\u2010LH effectively addresses the mechanical limitations of zwitterionic hydrogels and thus holds great potential for future clinical translation.<\/jats:p>","DOI":"10.1002\/advs.202508954","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:30:44Z","timestamp":1758036644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Concrete Structure Inspired\n                    <i>3D\u2010Printed<\/i>\n                    Framework Mechanically Reinforced Zwitterionic Hydrogel for Efficient Postoperative Abdominal Adhesion Prevention"],"prefix":"10.1002","volume":"12","author":[{"given":"Jianguo","family":"Song","sequence":"first","affiliation":[{"name":"College of Mechanical &amp; Energy Engineering Beijing University of Technology  Beijing 100124 China"},{"name":"Basic Research Key Laboratory of General Surgery for Digital Medicine Affiliated Hospital of Hebei University  Baoding 071000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Mechanical &amp; Energy Engineering Beijing University of Technology  Beijing 100124 China"},{"name":"Basic Research Key Laboratory of General Surgery for Digital Medicine Affiliated Hospital of Hebei University  Baoding 071000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Mechanical &amp; Energy Engineering Beijing University of Technology  Beijing 100124 China"},{"name":"Basic Research Key Laboratory of General Surgery for Digital Medicine Affiliated Hospital of Hebei University  Baoding 071000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Basic Research Key Laboratory of General Surgery for Digital Medicine Affiliated Hospital of Hebei University  Baoding 071000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-2988","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Mechanical &amp; Energy Engineering Beijing University of Technology  Beijing 100124 China"},{"name":"Basic Research Key Laboratory of General Surgery for Digital Medicine Affiliated Hospital of Hebei University  Baoding 071000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123289"},{"key":"e_1_2_8_2_1","first-page":"212","volume":"13","author":"Ruiz\u2010Esparza G. 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