{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:53:51Z","timestamp":1792119231590,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acetaminophen\u2010induced liver injury (AILI) is a major cause of acute liver failure, yet single\u2010target therapies like N\u2010acetylcysteine remain inadequate due to its complex pathogenesis. To address this challenge, we propose a dual\u2010action defense\u2010regeneration strategy that concurrently blocks multi\u2010death pathways and promotes hepatocyte regeneration. Specifically, the therapeutic metal gallium is doped into V\n                    <jats:sub>2<\/jats:sub>\n                    C MXene nanozymes (Ga\u2010V\n                    <jats:sub>2<\/jats:sub>\n                    C) to surpass conventional nanozymes by integrating sustained antioxidant activity for death signaling blockade, multi\u2010pathway regulation of cell death networks, and activation of pro\u2010regenerative molecules. In vivo, Ga\u2010V\n                    <jats:sub>2<\/jats:sub>\n                    C nanozymes exhibited superior protective efficacy over N\u2010acetylcysteine against AILI. Mechanistic investigations revealed that the Ga\u2010V\n                    <jats:sub>2<\/jats:sub>\n                    C nanozymes disrupt the synergistic amplification of liver injury by simultaneously inhibiting three key death pathways: oxidative stress (via ROS scavenging, reduce JNK phosphorylation, and activated Nrf2\/HO\u20101), apoptosis (via restored Bcl\u20102\/Bax balance), and ferroptosis (by suppressed iron\u2010dependent lipid peroxidation and upregulated SLC7A11\/FTH1\/FTL1). Notably, Ga\u2010V\n                    <jats:sub>2<\/jats:sub>\n                    C nanozymes fostered a pro\u2010regenerative microenvironment by activating Wnt\/\u03b2CAT pathways signaling and key cell cycle drivers (CCND1, MYC, PCNA), thereby enhancing hepatocyte regeneration. This work not only offers a promising therapeutic approach for AILI but also significantly expands the scope of nanozyme\u2010based therapeutics for complex diseases requiring multi\u2010target intervention.\n                  <\/jats:p>","DOI":"10.1002\/advs.202509079","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T09:42:03Z","timestamp":1767606123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gallium\u2010Doped MXene Nanozymes Protect Liver Through Multi\u2010Death Pathway Blockade and Hepatocyte Regeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaopeng","family":"Cai","sequence":"first","affiliation":[{"name":"Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou 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