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However, the widespread adoption of blood tests remains impeded by the lack of analytically validated biomarkers and accessible decentralized platforms. Here, the study presents a portable and automated micro\u2010immunobeads\u2010based electromagnetic operation system, termed MEMOs, targeting potential AD blood biomarker exosome\u2010bound A\u03b242 (Exo\u2010A\u03b242), for automated blood testing of AD. MEMOs integrates a microfluidic exosome\u2010detection biological chip (\u03bc\u2010Exo Biochip) embedded with a magnetic field\u2010responsive assay for detecting Exo\u2010A\u03b242 and a microbead operation electromagnetic chip (\u03bc\u2010Bead EMchip) for programmable and addressable actuation, collectively delivering a high level of accurate and automated AD testing. In both animal and clinical samples, the levels of Exo\u2010A\u03b242 measured using MEMOs have shown significant correlations with various progressive stages of AD. With the features of cost\u2010effective manufacturing, minimized hands\u2010on time, and an easy operation workflow, MEMOs offers an accessible pathway toward diagnosing and monitoring the progression of AD in decentralized practice.<\/jats:p>","DOI":"10.1002\/advs.202509376","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T10:01:32Z","timestamp":1755511292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Automated Micro\u2010Immunobeads\u2010Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1760-3302","authenticated-orcid":false,"given":"Xiaoxue","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering The University of Hong Kong Pokfulam Road Hong Kong SAR 000000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Ye","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine The University of Hong Kong Laboratory Block, Rm. 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K.","family":"Au Yeung","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering The University of Hong Kong Pokfulam Road Hong Kong SAR 000000 China"},{"name":"Advanced Biomedical Instrumentation Centre Hong Kong Science Park Shatin, New Territories Hong Kong SAR 000000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[{"name":"Advanced Biomedical Instrumentation Centre Hong Kong Science Park Shatin, New Territories Hong Kong SAR 000000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond Chuen\u2010Chung","family":"Chang","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine The University of Hong Kong Laboratory Block, Rm. 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