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Here, using human data, mechanistic exploration, and single\u2010cell RNA sequencing in mouse models of skin inflammation under stress challenge, prolactin is identified as a key mediator linking stress to inflammatory responses in the skin through an NR4A1\u2010midkine axis in\n                    <jats:italic>APCDD1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    fibroblasts in the upper dermis. The data shows that prolactin is increased in the plasma of psoriasis patients with high levels of stress and in stressed mice, which activates transcription factor NR4A1 in\n                    <jats:italic>APCDD1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    fibroblasts, promoting secretion of midkine, and amplification of immune infiltration and responses in neighboring cells. Targeting NR4A1 or midkine effectively reverses these inflammatory effects in vivo. These data provide a novel mechanism for stress\u2010related amplification of skin inflammation and identify NR4A1 and midkine as potential therapeutic targets to mitigate stress\u2010exacerbated inflammation.\n                  <\/jats:p>","DOI":"10.1002\/advs.202509679","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T05:33:41Z","timestamp":1762407221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Stress\u2010Induced Activation of Prolactin\u2010NR4A1\u2010Midkine Axis Exacerbates Skin Inflammation"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhiguo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University  Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of 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