{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:26:55Z","timestamp":1788809215341,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A signature of 16 serum proteins that were previously profiled using the aptamer\u2010based Somascan technology highlighted the roles of the e2 allele of\n                    <jats:italic>APOE<\/jats:italic>\n                    in lipid regulation via apolipoprotein B (APOB) and apolipoprotein E (APOE) and in inflammation. Here, the serum protein signature of\n                    <jats:italic>APOE<\/jats:italic>\n                    is validated and expanded using a combination of mass\u2010spectrometry, ELISA, Luminex, blood transcriptomics, and antibody\u2010based Olink serum proteomics. Some of the findings were replicated in the UK Biobank using antibody\u2010based Olink serum proteomics. This analysis replicated the association between APOB and the e2 allele of\n                    <jats:italic>APOE<\/jats:italic>\n                    , detected a new, robust pattern of association between\n                    <jats:italic>APOE<\/jats:italic>\n                    genotypes and the serum level of APOE, and discovered new associations between\n                    <jats:italic>APOE<\/jats:italic>\n                    genotypes and the complex of apolipoproteins APOC1, APOC2, APOC3, APOC4, APOE, APOF, and APOL1. In addition, 13 new proteins correlated with\n                    <jats:italic>APOE<\/jats:italic>\n                    genotypes. This extended signature includes granule proteins CAMP, CTSG, DEFA3, and MPO secreted from neutrophils and points to olfactomedin 4 (OLFM4) as a new target for the prevention of Alzheimer's disease.\n                  <\/jats:p>","DOI":"10.1002\/advs.202509764","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T10:02:46Z","timestamp":1764410566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6419-1545","authenticated-orcid":false,"given":"Paola","family":"Sebastiani","sequence":"first","affiliation":[{"name":"Institute for Clinical Research and Health Policy Studies Tufts Medical Center  Boston MA USA"},{"name":"School of Medicine Tufts University  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Reed","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin B","family":"Chandler","sequence":"additional","affiliation":[{"name":"Center for Biomedical Mass Spectrometry Department of Biochemistry and Cell Biology Boston University Chobanian &amp; Avedisian School of Medicine  Boston MA USA"},{"name":"Department of Cellular and Molecular Medicine Florida International University  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prisma","family":"Lopez","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research and Health Policy Studies Tufts Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Lords","sequence":"additional","affiliation":[{"name":"Division of Computational Biomedicine Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Bae","sequence":"additional","affiliation":[{"name":"College of Health Oregon State University  Corvallis OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E","family":"Costello","sequence":"additional","affiliation":[{"name":"Center for Biomedical Mass Spectrometry Department of Biochemistry and Cell Biology Boston University Chobanian &amp; Avedisian School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Au","sequence":"additional","affiliation":[{"name":"Chobanian &amp; Avedisian School of Medicine Boston University  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi Lynn","family":"Deng","sequence":"additional","affiliation":[{"name":"Chobanian &amp; Avedisian School of Medicine Boston University  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengze","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Computational Biomedicine Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyan","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heeju","family":"Noh","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Pflieger","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology  Seattle WA USA"},{"name":"Phenome Health  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory","family":"Funk","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Rappaport","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology  Seattle WA USA"},{"name":"Buck Institute for Research on Aging  Novato CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Epidemiology Biostatistics and Biodemography Department of Public Health University of Southern Denmark  DK Odense DK\u20105230 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan I","family":"Short","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research and Health Policy Studies Tufts Medical Center  Boston MA USA"},{"name":"School of Medicine Tufts University  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brent","sequence":"additional","affiliation":[{"name":"Epidemiology Biostatistics and Biodemography Department of Public Health University of Southern Denmark  DK Odense DK\u20105230 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Monti","sequence":"additional","affiliation":[{"name":"Division of Computational Biomedicine Department of Medicine Boston University Chobanian &amp; 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