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While much attention has focused on positive regulators of Treg differentiation and function, the mechanisms that constrain Treg transcriptional and metabolic programs remain poorly understood. Here, miR\u201010a is identified as a key negative regulator of Treg suppressive capacity and their crosstalk with intestinal epithelial cells. Single\u2010cell and bulk transcriptomic analyses reveal that Treg\u2010specific deletion of miR\u201010a promotes an effector Treg (eTreg) phenotype characterized by elevated Blimp1 expression, a direct target of miR\u201010a. MiR\u201010a\u2010deficient Tregs demonstrate enhanced suppressive capacity in alleviating colitis without compromising Treg stability. Mechanistically, miR\u201010a deficiency drives metabolic reprogramming, highlighted by altered mitochondrial oxidative phosphorylation through\n                    <jats:italic>Uqcrq<\/jats:italic>\n                    , a component of mitochondrial complex III. Loss of\n                    <jats:italic>Uqcrq<\/jats:italic>\n                    impairs Treg suppressive function in colitis but does not affect stability. Furthermore, miR\u201010a targets amphiregulin (Areg), an epidermal growth factor\u2010like molecule crucial for mucosal epithelial repair. Areg\u2010deficient Tregs exhibit decreased intestinal barrier function, whereas miR\u201010a\u2010deficient Tregs exhibit enhanced barrier function in experimental colitis. These findings define a multifaceted role for intrinsic miR\u201010a in negatively regulating Treg function by integrating transcriptional, metabolic, and epithelial repair pathways, thereby unveiling potential therapeutic interventions in inflammatory bowel diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.202509953","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:34:56Z","timestamp":1762162496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intrinsic MicroRNA\u201010a Restricts Regulatory T Cell Suppressive Function and Intestinal Repair by Coordinating Transcriptional, Metabolic, and Epithelial Repair Pathways"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1541-1892","authenticated-orcid":false,"given":"Wenjing","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology 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