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Microorganisms can\n                    <jats:italic>S<\/jats:italic>\n                    \u2010methylate H\n                    <jats:sub>2<\/jats:sub>\n                    S and MeSH, which can be cytotoxic, to yield non\u2010toxic DMS via MddA or MddH enzymes in largely terrestrial or marine environments, respectively. However, the potential of many important and abundant bacteria like\n                    <jats:italic>Actinomycetota<\/jats:italic>\n                    is underestimated due to unknown Mdd enzymes. Here, two novel\n                    <jats:italic>S<\/jats:italic>\n                    \u2010adenosine\u2010methionine\u2010dependent H\n                    <jats:sub>2<\/jats:sub>\n                    S and MeSH\n                    <jats:italic>S<\/jats:italic>\n                    \u2010methyltransferases, MddM1 and MddM2 are identified, in the DMS\u2010producing actinomycete\n                    <jats:italic>Mycolicibacterium poriferae<\/jats:italic>\n                    (\n                    <jats:italic>M. poriferae<\/jats:italic>\n                    ) ZYF656, isolated from the Mariana Trench.\n                    <jats:italic>M. poriferae<\/jats:italic>\n                    ZYF656 MddM1 and MddM2 likely detoxify H\n                    <jats:sub>2<\/jats:sub>\n                    S and MeSH and alleviate oxidative stress, since\n                    <jats:italic>mddM1<\/jats:italic>\n                    and\n                    <jats:italic>mddM2<\/jats:italic>\n                    transcription is induced by H\n                    <jats:sub>2<\/jats:sub>\n                    S, MeSH, and oxidative stress, and their expression in\n                    <jats:italic>E. coli<\/jats:italic>\n                    enhances H\n                    <jats:sub>2<\/jats:sub>\n                    S, MeSH, and oxidative stress tolerance. MddM1 and\/or MddM2 are in &gt;50% of\n                    <jats:italic>actinomycetota<\/jats:italic>\n                    , including the model\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    species,\n                    <jats:italic>S. venezuelae<\/jats:italic>\n                    , but are also seen in some\n                    <jats:italic>Chloroflexota<\/jats:italic>\n                    ,\n                    <jats:italic>Acidobacteriota<\/jats:italic>\n                    , and\n                    <jats:italic>Proteobacteria<\/jats:italic>\n                    .\n                    <jats:italic>mddM1<\/jats:italic>\n                    is always more abundant than\n                    <jats:italic>mddM2<\/jats:italic>\n                    in diverse environments and is prevalent in soils and marsh sediments. This study highlights the significance of H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010 and MeSH\u2010dependent DMS production and, principally, of\n                    <jats:italic>Actinomycetota<\/jats:italic>\n                    in global DMS production and sulfur cycling.\n                  <\/jats:p>","DOI":"10.1002\/advs.202510141","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T09:04:44Z","timestamp":1764752684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Two Novel\n                    <i>S<\/i>\n                    \u2010methyltransferases Confer Dimethylsulfide Production in\n                    <i>Actinomycetota<\/i>"],"prefix":"10.1002","volume":"13","author":[{"given":"Ruihong","family":"Guo","sequence":"first","affiliation":[{"name":"Frontiers Science Center for Deep Ocean Multispheres and Earth System, and College of Marine 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