{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:41:31Z","timestamp":1787503291090,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373139"],"award-info":[{"award-number":["82373139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630072"],"award-info":[{"award-number":["81630072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273133"],"award-info":[{"award-number":["82273133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303028"],"award-info":[{"award-number":["82303028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203243"],"award-info":[{"award-number":["82203243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515030261"],"award-info":[{"award-number":["2023A1515030261"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013206"],"award-info":[{"award-number":["2024A1515013206"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012612"],"award-info":[{"award-number":["2025A1515012612"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202206010167"],"award-info":[{"award-number":["202206010167"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2020YFA0803300"],"award-info":[{"award-number":["2020YFA0803300"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pancreatic ductal adenocarcinoma (PDAC) is a fatal cancer with poor prognosis. COP9 signalosome subunit 6 (CSN6), a key regulator of different E3 ubiquitin ligases, plays oncogenic roles in various cancers. However, its function in PDAC remains elusive. Here, this demonstrates that human PDAC tumors expressing high levels of CSN6 present with poor prognosis and gemcitabine resistance. Conditional knockout (KO) of CSN6 hinders tumor formation in a KPP spontaneous PDAC mouse model. Proteomic analysis indicates that CSN6 promotes ribosome biogenesis by activating rDNA transcription and protein synthesis. Mechanistically, CSN6 antagonizes DDB1\u2010CUL4 associated factor 1 (DCAF1)\u2010mediated ubiquitination of Nucleophosmin (NPM1), thereby promoting NPM1\u2010orchestrated ribosome biogenesis. In line with CSN6\u2010mediated gemcitabine resistance, CSN6\u2010NPM1 axis enhances ribosome biogenesis, thereby promoting translation of gemcitabine resistance genes, including Cytidine deaminase (CDA), Ribonucleotide reductase subunit M1\/2 (RRM1\/2). Significantly, combining gemcitabine with NPM1 inhibitor NSC348884 synergistically suppresses CSN6\u2010high pancreatic cancer xenografts. Clinically, CSN6 expression positively correlates with NPM1 in PDAC tissues, and their concurrent high expression is significantly associated with poor clinical outcomes. This study characterizes CSN6 as an oncogenic protein that promotes NPM1 stabilization by interacting with DCAF1, thereby enhancing ribosome biogenesis and cellular resistance to gemcitabine in PDAC. NPM1 may serve as a therapeutic target for CSN6 high PDAC that exhibits gemcitabine drug resistance.<\/jats:p>","DOI":"10.1002\/advs.202510210","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:52:05Z","timestamp":1760971925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1\u2010Mediated Ubiquitination of NPM1"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2575-3776","authenticated-orcid":false,"given":"Yijing","family":"Zhang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiwen","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwen","family":"Lyu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongmin","family":"Fan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Yi","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihao","family":"Pan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidan","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baifu","family":"Qin","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Medical Virology School of Medicine Jinan University  Guangzhou Guangdong Province 510632 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqi","family":"Meng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-8215","authenticated-orcid":false,"given":"Mong\u2010Hong","family":"Lee","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Guangdong Institute of Gastroenterology  Guangzhou 510655 China"},{"name":"Department of Oncology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.16"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.06.042"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117443"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.023"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6384"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.07.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44111"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4731"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0779-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306827"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01405-8"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-2145"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2019.1632143"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks162"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13599"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02476-4"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-4087"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01285-4"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.10.033"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.646"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.04.023"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.07.025"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1475506"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16469"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14070882"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601221"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231071698"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-309674"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2013.04.001"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2015.10.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.54"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065506"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15755"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-0557"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.10.3798-3809.2006"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004226"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010140"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd6078"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.04.100"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37883-1"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-023-02685-8"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225758"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00771-8"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252917"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100881"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-019-00154-7"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03898-8"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46521-3"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0649"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000681"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202510210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202510210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202510210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:58:54Z","timestamp":1774270734000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202510210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/advs.202510210"],"URL":"https:\/\/doi.org\/10.1002\/advs.202510210","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"assertion":[{"value":"2025-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10210"}}