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Early small plaques cannot be accurately detected using traditional Magnetic resonance imaging (MRI) probes. Therefore, magnetic resonance tuning (MRET) and susceptibility weighted imaging (SWI)\u2010based smart responsive MR nanoprobes are designed to achieve the sensitive detection of BACE1 and A\u03b2 plaques. This probe is modified with a blood\u2010brain barrier\u2010penetrating targeting peptide that enables its reach to the AD microenvironment. The enhancement of T1WI signals owing to the MRET effect caused by the separation of probes in response to BACE1 is used to reflect real\u2010time BACE1 changes. When A\u03b2 plaques are present, the remaining probes that bound around A\u03b2 plaques underwent in situ thiol cross\u2010linking under the action of peroxynitrite (ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) in the AD microenvironment, and SWI can magnify magnetic susceptibility differences, which significantly increased the A\u03b2 plaque detection sensitivity. This probe combines the advantages of T1WI and SWI and can simultaneously visualize and reflect the BACE1 level and A\u03b2 plaque distribution. This approach overcomes the limitations of traditional single\u2010target probes and provides a new noninvasive and highly accurate strategy for the early diagnosis of AD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202510298","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:25:16Z","timestamp":1761657916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["T1WI\u2010SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Minghua","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Tongji Hospital School of Medicine Tongji University  Shanghai 200092 P. R. China"},{"name":"Institute of Medical Imaging Artificial Intelligence Tongji University School of Medicine  Shanghai 200092 P. R. 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