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Although dipolar interactions likely contribute to contrast enhancement, their role in magnetic inhomogeneities and proton dephasing remains poorly understood, limiting further optimization. In this study, the fundamental role of dipolar interactions on the modulation of the transverse relaxivity (r\n                    <jats:sub>2<\/jats:sub>\n                    ) of iron oxide\u2010based CAs is demonstrated by shaping local magnetic field inhomogeneities. A nanoscale\u2010distance\u2010tuned model system is developed by coating superparamagnetic iron oxide nanoprobes with silica shells of increasing thickness, thereby modulating the intensity of the dipolar interactions. An exponential dependence of r\n                    <jats:sub>2<\/jats:sub>\n                    on dipolar interaction strength is observed, with a sharp initial increase followed by a plateau as interactions reached their effective range, resulting in up to a sevenfold enhancement compared to interaction\u2010free CAs. Furthermore, the dependence of r\n                    <jats:sub>2<\/jats:sub>\n                    on B\n                    <jats:sub>0<\/jats:sub>\n                    is evaluated across conventional field\u2010MRI (1.4 and 3.0 T) to UHF\u2010MRI (7.0 and 11.7 T), in both interacting and non\u2010interacting CA systems, revealing a nonlinear behavior. These findings establish dipolar interaction control as a key parameter for optimizing T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010CAs performance, advancing the design of next\u2010generation MRI nanoprobes for diagnostic applications.\n                  <\/jats:p>","DOI":"10.1002\/advs.202510356","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:15:50Z","timestamp":1762280150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling Dipolar Interaction\u2010Driven Magnetic Field Inhomogeneities in T\n                    <sub>2<\/sub>\n                    MRI Contrast Agents"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-6772","authenticated-orcid":false,"given":"Pelayo","family":"Garc\u00eda\u2010Acevedo","sequence":"first","affiliation":[{"name":"NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute and Health Research Institute of Santiago de Compostela (IDIS) Universidade de Santiago de Compostela  Santiago de Compostela 15782 Spain"},{"name":"Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC) Health Research Institute of Santiago de Compostela (IDIS) Santiago de Compostela 15706 Spain"},{"name":"Advanced (magnetic) Theranostic Nanostructures Lab International Iberian Nanotechnology Laboratory Braga 4715\u2010330 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4614-1629","authenticated-orcid":false,"given":"Yolanda","family":"Pi\u00f1eiro","sequence":"additional","affiliation":[{"name":"NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute and Health Research Institute of Santiago de Compostela (IDIS) Universidade de Santiago de Compostela  Santiago de Compostela 15782 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-3234","authenticated-orcid":false,"given":"Juan","family":"Gallo","sequence":"additional","affiliation":[{"name":"Advanced (magnetic) Theranostic Nanostructures Lab International Iberian Nanotechnology Laboratory Braga 4715\u2010330 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0368-7031","authenticated-orcid":false,"given":"Pedro","family":"Ramos\u2010Cabrer","sequence":"additional","affiliation":[{"name":"Center for Cooperative Research in Biomaterials (CIC biomaGUNE) Basque Research and Technology Alliance (BRTA) Donostia\u2010San Sebasti\u00e1n 20014 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-9135","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Iglesias\u2010Rey","sequence":"additional","affiliation":[{"name":"Neuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC) Health Research Institute of Santiago de Compostela (IDIS) Santiago de Compostela 15706 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-3196","authenticated-orcid":false,"given":"Jos\u00e9","family":"Rivas","sequence":"additional","affiliation":[{"name":"NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute and Health Research Institute of Santiago de Compostela (IDIS) Universidade de Santiago de Compostela  Santiago de Compostela 15782 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-2631","authenticated-orcid":false,"given":"Manuel","family":"Ba\u00f1obre\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Advanced (magnetic) Theranostic Nanostructures Lab International Iberian Nanotechnology Laboratory Braga 4715\u2010330 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201804567"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201906539"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr100025t"},{"key":"e_1_2_8_4_1","first-page":"1727","volume":"10","author":"Estelrich J.","year":"2015","journal-title":"Int. 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