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Due to incompletely understood regulatory mechanisms, effective solutions for early diagnosis and minimally invasive therapy remain lacking. In this study, plsama circPROSC is first identified as an independent risk factor for craniosynostosis. Through MSCs osteogenic differentiation and nude mouse ectopic bone formation assays, circPROSC promotes osteogenesis via miR\u20106815\u20105p\u2010mediated modulation of the Wnt signaling pathway. Furthermore, MSC membrane\u2010coated siRNA nanoparticles (MM@Lipo\/siRNA) targeting circPROSC (si\u2010circPROSC) have been developed to inhibit its expression in the coronal suture by postnatal cranial microinjection, which attenuated premature coronal suture closure in a craniosynostosis mouse model. 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