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Through comprehensive single\u2010cell transcriptomic profiling of ENZ\u2010na\u00efve and ENZ\u2010treated tumors, an expansion of ENZ\u2010resistant myofibroblastic cancer\u2010associated fibroblast (designated STEAP4\n                    <jats:sup>+<\/jats:sup>\n                    myoCAF) is identified that correlates with adverse clinical outcomes. Strikingly, STEAP4\n                    <jats:sup>+<\/jats:sup>\n                    myoCAF demonstrated intrinsic ENZ resistance through a mechanistically novel pathway involving transcription factor binding to IGHM enhancer 3 (TFE3)\u2010mediated autophagy activation. Integrated lipidomic and functional analyses revealed that TFE3 activation drives phosphatidylcholine overproduction via direct upregulation of phosphate cytidylyltransferase 1A (PCYT1A), establishing a tumor\u2010promoting feedforward loop. The resultant phospholipid\u2010rich microenvironment activates an HSP90\/HIF1A signaling axis in malignant epithelial cells, fueling cancer stemness and therapeutic escape. These findings position the STEAP4\n                    <jats:sup>+<\/jats:sup>\n                    myoCAF\u2010TFE3\/tumor\u2010HIF1A axis as a master regulator of anti\u2010androgen resistance, offering clinically actionable targets to extend treatment efficacy in advanced prostate cancer.\n                  <\/jats:p>","DOI":"10.1002\/advs.202510602","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:38:01Z","timestamp":1757327881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enzalutamide\u2010Resistant STEAP4\n                    <sup>+<\/sup>\n                    MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone\u2010Sensitive Prostate Cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"Wenhao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology School of Medicine Shanghai General 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