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Here, leveraging single\u2010cell RNA sequencing, the fibrotic landscape of NB is delineated and a distinct integrin \u03b18 (Itga8) \u207a fibroblast population. The Itga8\u207a fibroblasts expand substantially during the acute phase post\u2010injury and exhibit a fibrogenic transcriptional profile. Mechanistically, Itga8 is found to coordinate cytoskeletal remodeling via the FAK\/RhoA\/ROCK signaling to facilitate fibroblast activation. Moreover, fibroblast activation is orchestrated by Trem2\u207a macrophages, which secrete Fn1 to engage Itga8 on fibroblasts, thereby reinforcing the pro\u2010fibrotic communication between fibroblasts and macrophages. Notably, macrophage depletion markedly attenuates fibrosis and restores bladder function, underscoring their pivotal role in NB pathogenesis. In vivo, conditional deletion of\n                    <jats:italic>Itga8<\/jats:italic>\n                    (\n                    <jats:italic>Col1a2<\/jats:italic>\n                    \u2010CreERT;\n                    <jats:italic>Itga8<\/jats:italic>\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    ) or local knockdown of\n                    <jats:italic>Itga8<\/jats:italic>\n                    significantly attenuates collagen deposition and improves voiding efficiency. Collectively, this study reveals a novel Itga8\u2010centered fibroinflammatory axis and nominates Itga8 as a promising therapeutic target for delaying fibrosis progression and restoring bladder function.\n                  <\/jats:p>","DOI":"10.1002\/advs.202510631","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T09:29:52Z","timestamp":1765186192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2\u207a Macrophage\u2010Derived Fn1 via FAK\/RhoA\/ROCK Signaling"],"prefix":"10.1002","volume":"13","author":[{"given":"Jiaxin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"},{"name":"Institute of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and 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