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Current treatments, including surgery, radiation, and chemotherapy, frequently lead to recurrence, underscoring the urgent need for innovative solutions. This work develops and evaluates bioinspired adhesive membranes designed as novel strategy to address glioblastoma recurrence post\u2010surgery. Inspired by mussel adhesion, these membranes exhibit strong bioadhesion in wet environments and incorporate various phenolic\u2010based compounds. Among tested combinations, a membrane with catechin demonstrates specific cytotoxic effect on human glioblastoma cells. This effect is investigated through in vitro assays using glioblastoma cell lines, including primary cell cultures. Exposure to this membrane induces changes in cell morphology and internal structures, and alterations in cell adhesion and migration. Additionally, the use of glioblastoma spheroids and ex vivo tissues allow us to mimic glioblastoma microenvironment and assess the membrane efficacy. Reactive oxygen species are suggested to play a main role in the cytotoxic effect, counteracted by the antioxidant N\u2010acetylcysteine. Finally, a comprehensive proteomic study elucidates biological mechanisms underlying the membrane performance. This research highlights the potential of mussel\u2010inspired advanced scaffolds as a localized approach in glioblastoma therapy, suggesting a path for effective anticancer strategies.<\/jats:p>","DOI":"10.1002\/advs.202510658","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T15:55:03Z","timestamp":1769529303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Mussel\u2010Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9931-1615","authenticated-orcid":false,"given":"Jose","family":"Bola\u00f1os\u2010Cardet","sequence":"first","affiliation":[{"name":"Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST  Bellaterra Spain"},{"name":"Cell Death Senescence and Survival Group Departament De Bioqu\u00edmica i Biologia Molecular and Institut de Neuroci\u00e8ncies Facultat de Medicina Campus De Bellaterra Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1077-9180","authenticated-orcid":false,"given":"Sara","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BIST  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-5047","authenticated-orcid":false,"given":"Jordi","family":"Bruna","sequence":"additional","affiliation":[{"name":"Unit of Neuro\u2010Oncology Hospital Universitari de Bellvitge\u2010Institut Catal\u00e0 Oncologia Bellvitge Institute for Biomedical Research (IDIBELL) L'Hospitalet De Llobregat  Spain"},{"name":"Department of Cell Biology Physiology and Immunology Universitat Aut\u00f2noma de Barcelona  Bellaterra 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