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Here this work investigates the potential connection between cognitive\u2010enhancing effect and TNEA in 5\u00d7familial Alzheimer disease\uff085xFAD) mice model, a model characterized by Amyloid\u2010beta (A\u03b2) pathology. This work finds alterations in gamma\/theta oscillations and deficits in inhibitory monosynaptic transmission in the hippocampal CA1 region of AD. Parvalbumin\u2010positive (PV\n                    <jats:sup>+<\/jats:sup>\n                    ) interneurons are crucial for generating gamma oscillations and modulating theta oscillation, thereby maintaining the excitation\u2010inhibition (E\/I) balance in local neural circuits. In 5xFAD mice, TNEA modulated PV\n                    <jats:sup>+<\/jats:sup>\n                    interneuron function, enhancing gamma oscillations during quiescent states. Furthermore, during the novel object recognition test (NORT), TNEA increased theta oscillation power by strengthening presynaptic inhibitory interneurons involved in monosynaptic connections. Collectively, these findings suggest TNEA is a viable minimally invasive treatment approach for AD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202510885","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:11:51Z","timestamp":1762848711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-9729","authenticated-orcid":false,"given":"Zhongzhao","family":"Guo","sequence":"first","affiliation":[{"name":"Rehabilitation Center Tongren Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200336 China"},{"name":"School of Integrative Medicine Shanghai University of Traditional Chinese Medicine  Shanghai 201203 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