{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:44:37Z","timestamp":1784137477933,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170204"],"award-info":[{"award-number":["82170204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870165"],"award-info":[{"award-number":["81870165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Immune checkpoint inhibitors (ICIs) have transformed the treatment of many solid tumors. Still, their effectiveness in multiple myeloma (MM) remains underwhelming, highlighting the need to explore alternative approaches beyond conventional ICIs. Here, CD161 is identified as a novel inhibitory receptor on bone marrow (BM) tissue resident memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells (CD8\n                    <jats:sup>+<\/jats:sup>\n                    TRM), known for their sustained presence and vital role in local immune surveillance in MM BM tumor microenvironments. The CD161\u2013CLEC2D axis, where CD161 interacts with CLEC2D on MM cells, mediates immune suppression and TRM dysfunction. Blocking CD161 enhances TRM function, including tissue residency, proliferation, and antitumor activity. CD161 blockade significantly alleviates chimeric antigen receptor T\u2010cell (CAR\u2010T) exhaustion and enhances their antimyeloma function ex vivo. These findings identified the CD161\u2013CLEC2D pathway as a potential novel target for immunotherapy of MM.\n                  <\/jats:p>","DOI":"10.1002\/advs.202510888","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T05:20:27Z","timestamp":1756185627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeting of the CD161 Inhibitory Receptor Enhances Bone\u2010Marrow\u2010Resident Memory CD8\n                    <sup>+<\/sup>\n                    T\u2010Cell\u2010Mediated Immunity against Multiple Myeloma"],"prefix":"10.1002","volume":"12","author":[{"given":"Liwen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhi","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiebin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-7522","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Third Xiangya Hospital Central South University  Changsha Hunan Province 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.0003"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0068-5"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00593-y"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00763-8"},{"key":"e_1_2_9_2_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31430-0"},{"key":"e_1_2_9_2_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0269-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21771"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-775122"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo3420"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30109-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-0053-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127807"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-166580"},{"key":"e_1_2_9_6_3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-131349"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01829"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-179162"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.016"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.022"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022882"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1325-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00803-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-008694"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-008667"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.041"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015522"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.11.019"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05128-8"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-018-2160-x"},{"key":"e_1_2_9_16_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00629-w"},{"key":"e_1_2_9_16_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.037"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.138970"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.09.013"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003323"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq2987"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26951-z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-1769"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02371-y"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2035"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.08.011"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-23-0547"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202510888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:32:44Z","timestamp":1763119964000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202510888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":40,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/advs.202510888"],"URL":"https:\/\/doi.org\/10.1002\/advs.202510888","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,25]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10888"}}