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Among these, alkoxycarbonyl radical\u2010mediated functionalization strategies\u00a0have emerged as a highly efficient and versatile tool for the synthesis of these compounds. Despite the significant advancements in recent years, the radical\u2010induced enantioselective alkoxycarbonylation reaction remains largely unexplored. Herein, a highly enantioselective alkoxycarbonyl\u2010lactonization of alkenes is reported through a photoredox\/copper dual\u2010catalyzed alkoxycarbonyl radical addition\/cyclization reaction. With this approach, a diverse array of ester\u2010substituted chiral \u03b3\u2010butyrolactones bearing a quaternary stereocenter can be readily obtained in high yields and with excellent enantioselectivities under mild reaction conditions. This versatile method shows good substrate tolerance for primary, secondary, and tertiary alcohol derivatives while maintaining exceptional stereochemical control.<\/jats:p>","DOI":"10.1002\/advs.202510918","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T12:21:28Z","timestamp":1755087688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enantioselective Alkoxycarbonyl\u2010Lactonization of Alkenes via the Merger of Photoredox and Copper Catalysis"],"prefix":"10.1002","volume":"12","author":[{"given":"Yuping","family":"Xiong","sequence":"first","affiliation":[{"name":"School of Pharmaceutical and Chemical Engineering &amp; Institute for Advanced Studies Taizhou University  Taizhou 318000 China"},{"name":"School of Chemistry and Chemical Engineering Hunan University of Science and Technology  Xiangtan 411201 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Zong","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical and Chemical Engineering &amp; Institute for Advanced Studies Taizhou University  Taizhou 318000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlin","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Hunan University of Science and Technology  Xiangtan 411201 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-9069","authenticated-orcid":false,"given":"Jian\u2010Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical and Chemical Engineering &amp; Institute for Advanced Studies Taizhou University  Taizhou 318000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical and Chemical Engineering &amp; Institute for Advanced Studies Taizhou University  Taizhou 318000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-6360","authenticated-orcid":false,"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical and Chemical Engineering &amp; Institute for Advanced Studies Taizhou University  Taizhou 318000 China"},{"name":"State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2468"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.46"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2010.09.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557521666210105110848"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2016.1187598"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/9781849731102-00099"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2586"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300100s"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200900013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/1381-1169(95)00130-1"},{"key":"e_1_2_8_11_1","first-page":"113","volume-title":"Transition Metals for Organic Synthesis","author":"Ali B. 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