{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:18:26Z","timestamp":1792513106017,"version":"4.5.0"},"reference-count":63,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2023S030"],"award-info":[{"award-number":["2023S030"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32\u00a0201\u00a0139"],"award-info":[{"award-number":["32\u00a0201\u00a0139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The treatment of orthopedic implant\u2013associated infections (IAIs)\u00a0presents significant challenges due to increasing drug resistance. This study reports a virulence\u2010selective trap\u2013capture\u2013kill antibacterial system for effectively treating persistent infections while promoting local bone tissue regeneration by regulating disordered immune and metabolic microenvironments caused by IAIs. Here, this work fabricates a nanostructured antibacterial system (F\u201014\u2010TNA) based on a TiO\n                    <jats:sub>2<\/jats:sub>\n                    nanotube array modified with a cationic pentacyclic coplanar backbone, fascaplysin derivative 14 (F\u201014). The modified surface induces a unique virulence\u2010initiated chemotaxis behavior, with the TiO\n                    <jats:sub>2<\/jats:sub>\n                    nanostructure selectively trapping hyperpathogenic bacterial strains from the infecting microbiota. These trapped bacterial strains are subsequently captured by the positively charged F\u201014 surface via electrostatic force. The virulence\u2010selective bacteria are then killed via a reactive oxygen species\u2013mediated pathway regulated by the phosphotransferase system cyclic adenosine monophosphate receptor protein cascade. In vitro and in vivo studies reveal that F\u201014\u2010TNA has multiple biocompatibility functions, such as effective antibacterial activity, regulation of the immune microenvironment of bone infections, and recovery of disordered bone metabolism. The nanostructure developed in this study provides a novel approach for the treatment of IAIs.\n                  <\/jats:p>","DOI":"10.1002\/advs.202511045","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T13:36:14Z","timestamp":1757943374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Virulence\u2010Selective Trap\u2013Capture\u2013Kill Antibacterial Nanostructures With Immune\u2013Metabolic Regulation for Treating Implant\u2010Associated Infections"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaodong","family":"Hu","sequence":"first","affiliation":[{"name":"Affiliated Li Huili Hospital Ningbo University  Ningbo 315040 China"},{"name":"Health Science Center Ningbo University  Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Affiliated Li Huili Hospital Ningbo University  Ningbo 315040 China"},{"name":"Health Science Center Ningbo University  Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Li Huili Hospital Ningbo University  Ningbo 315040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botao","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Li Huili Hospital Ningbo University  Ningbo 315040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Du","sequence":"additional","affiliation":[{"name":"Health Science Center Ningbo University  Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Peking University First Hospital  Beijing 100034 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhe","family":"Zheng","sequence":"additional","affiliation":[{"name":"Affiliated Li Huili Hospital Ningbo University  Ningbo 315040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongze","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province School of Materials Science and Chemical Engineering Ningbo University  Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Ni","sequence":"additional","affiliation":[{"name":"College of Biological Science and Medical Engineering Donghua University  Shanghai 201620 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4100","authenticated-orcid":false,"given":"Zhaoxiang","family":"Peng","sequence":"additional","affiliation":[{"name":"Affiliated Li Huili Hospital Ningbo University  Ningbo 315040 China"},{"name":"Health Science Center Ningbo University  Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121663"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202405953"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads8694"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202419426"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158946"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303374"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122268"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.04.040"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113737"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2022.09.029"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202316093"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.128123"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b02217"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.02.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.114099"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115348"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.07.014"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2203477"},{"key":"e_1_2_9_19_1","first-page":"3093","author":"Peng Z.","year":"2013","journal-title":"Int. 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