{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:12:00Z","timestamp":1792293120790,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302359"],"award-info":[{"award-number":["82302359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011822"],"award-info":[{"award-number":["2023A1515011822"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515140024"],"award-info":[{"award-number":["2024A1515140024"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017369","name":"Scientific and Technological Planning Project of Guangzhou City","doi-asserted-by":"publisher","award":["2023A03J0215"],"award-info":[{"award-number":["2023A03J0215"]}],"id":[{"id":"10.13039\/100017369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multifunctional small\u2010molecule theranostic agents hold significant clinical potential for non\u2010invasive endometriosis (EMS) management. Current EMS treatment faces challenges due to imprecise lesion localization and therapy\u2010associated side effects. Herein, an integrated theranostic probe, cRGDyK\u2010ICG\u2010Lys\u2010DTPA@Gd (cRGD\u2010ILD), designed for concurrent precise lesion localization and targeted phototherapy in EMS, is developed. This molecular probe integrates three key functional components: the DTPA@Gd complex provides contrast for magnetic resonance imaging, the ICG fragment enables fluorescence imaging and photoacoustic imaging while serving as the phototherapeutic agent, and the cRGD peptide targets integrin\n                    <jats:italic>\u03b1<\/jats:italic>\n                    <jats:sub>v<\/jats:sub>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sub>3<\/jats:sub>\n                    receptors to facilitate precise accumulation in ectopic endometrial tissue. Specifically, cRGD\u2010ILD leverages its small size and receptor\u2010mediated transcytosis to penetrate neovascularized tissue and target ectopic endometrial cells. Under 808\u00a0nm laser irradiation, the ICG moiety generates reactive oxygen species and heat, exerting combined photodynamic and photothermal therapeutic effects that effectively suppress lesion progression in both autografted EMS rats and xenografted nude mice. Notably, composed of clinically available and FDA\u2010approved constituents, the probe demonstrates favorable biocompatibility and biosafety for in vivo applications. Overall, this well\u2010designed molecular probe enables precise multimodal imaging guidance and localized phototherapy for EMS.\n                  <\/jats:p>","DOI":"10.1002\/advs.202511126","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T06:57:19Z","timestamp":1756450639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Multifunctional Molecular Probe for Multimodal Imaging\u2010Guided Potent Photothermal\/Photodynamic Therapy of Endometriosis"],"prefix":"10.1002","volume":"12","author":[{"given":"Qiyu","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Gynecology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouzhou","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5575-3582","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target &amp; Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences Guangzhou Medical University  Guangzhou 511436 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-0310","authenticated-orcid":false,"given":"Xintao","family":"Shuai","sequence":"additional","affiliation":[{"name":"Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-5809","authenticated-orcid":false,"given":"Shuqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"},{"name":"Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad020"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.232191"},{"key":"e_1_2_8_3_1","first-page":"31","volume":"74","author":"Sorrentino F.","year":"2022","journal-title":"Minerva Obstetr. Gynecol."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead262"},{"key":"e_1_2_8_5_1","volume":"10","author":"Bafort C.","year":"2020","journal-title":"Laparoscop. Surg. Endometr."},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2217\/whe.15.56"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21802"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.220148"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.2018027414"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302175"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.12.017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2018.14"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07377"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09664"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1216210"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2009.157"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.05.012"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-20-845"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2022.3165839"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/rycan.239017"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.08.038"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0775-9"},{"key":"e_1_2_8_17_1","first-page":"5418","volume":"18","author":"Ma Y.","year":"2024","journal-title":"ACS Nano"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.5.736"},{"key":"e_1_2_8_17_3","volume":"11","author":"Zhang L.","year":"2023","journal-title":"Biomedicines"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn402662d"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.006"},{"key":"e_1_2_8_18_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.04.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201603270"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06182-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105539"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0410-2"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207694"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00599-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.233482"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909117"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11269-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-022-4599-5"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(02)00818-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901616"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.02.027"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.12.015"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2007.07.004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.05.020"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02784-4"},{"key":"e_1_2_8_33_3","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey055"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00891"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00618K"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201906936"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)48988-0"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB00668A"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22454-z"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-20-0033"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2010.08.008"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c00500"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202511126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202511126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202511126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:04:45Z","timestamp":1790251485000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202511126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":55,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/advs.202511126"],"URL":"https:\/\/doi.org\/10.1002\/advs.202511126","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e11126"}}