{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:00:27Z","timestamp":1783461627052,"version":"3.55.0"},"reference-count":68,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DQ20170336751"],"award-info":[{"award-number":["DQ20170336751"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201018\u2010RHUS\u20100012"],"award-info":[{"award-number":["ANR\u201018\u2010RHUS\u20100012"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010390","name":"Saint Louis University","doi-asserted-by":"publisher","award":["Institute for Translational Neuroscience"],"award-info":[{"award-number":["Institute for Translational Neuroscience"]}],"id":[{"id":"10.13039\/100010390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["HT9425\u201023\u20101\u20100853"],"award-info":[{"award-number":["HT9425\u201023\u20101\u20100853"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS119263\u201004S1"],"award-info":[{"award-number":["R01NS119263\u201004S1"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood. Autoantibodies against fibroblast growth factor receptor 3 define a subset of patients with consistent reports of neuropathic pain harboring a distinct clinical phenotype characterized by small\u2010fiber and non\u2010length\u2010dependent neuropathy, suggesting dorsal root ganglia (DRG) dysfunction. FGFR3\u2010autoantibody\u2010positive sera (FGFR3\u2010AbS) bind to sensory neurons within dorsal root ganglia (DRG). The target of autoantibodies FGFR3 is expressed at the transcript and protein level in human sensory neurons, suggesting that FGFR3\u2010AbS could find their target in primary afferents. DRG neurons exposed to FGFR3\u2010AbS rapidly acquired a hyperexcitability phenotype which was linked to mechanical hypersensitivity, mirroring patient\u2010reported pain symptoms. CRISPR mediated gene editing of FGFR3 in sensory neuron prevented FGFR3\u2010AbS induced sensitization of sensory neurons and mechanical hypersensitivity. In parallel, epitope mapping reveals extracellular FGFR3 epitopes essential for antibody\u2010induced sensitization and pain hypersensitivity. Together this work suggests that beyond their role as biomarkers, FGFR3\u2010AbS are pathogenic in small fiber neuropathy by acting directly on DRG neurons. This positions both FGFR3\u2010AbS and FGFR3 signaling as actionable therapeutic targets for modulating sensory neuron excitability and treating autoimmune painful neuropathies.<\/jats:p>","DOI":"10.1002\/advs.202511413","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:49:13Z","timestamp":1771332553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy"],"prefix":"10.1002","volume":"13","author":[{"given":"Lyuba Y.","family":"Salih","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology Saint Louis University School of Medicine  Saint Louis Missouri USA"},{"name":"Institute For Translational Neuroscience Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas L.A.","family":"Dumaire","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Saint Louis University School of Medicine  Saint Louis Missouri USA"},{"name":"Institute For Translational Neuroscience Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Gier\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Saint Louis University School of Medicine  Saint Louis Missouri USA"},{"name":"Institute For Translational Neuroscience Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Vest","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Saint Louis University School of Medicine  Saint Louis Missouri USA"},{"name":"Institute For Translational Neuroscience Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haya","family":"Alkhateeb","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Saint Louis University School of Medicine  Saint Louis Missouri USA"},{"name":"Institute For Translational Neuroscience Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P.","family":"Moritz","sequence":"additional","affiliation":[{"name":"MeLiS | CNRS UMR 5284 | INSERM U1314, Synaptopathies and Autoantibodies, Institut National de La Sant\u00e9 et De La Recherche M\u00e9dicale (INSERM), U1217 Centre National de la Recherche Scientifique (CNRS) UMR5310  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1, 69000 Lyon France and University Jean Monnet  Saint\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Tholance","sequence":"additional","affiliation":[{"name":"MeLiS | CNRS UMR 5284 | INSERM U1314, Synaptopathies and Autoantibodies, Institut National de La Sant\u00e9 et De La Recherche M\u00e9dicale (INSERM), U1217 Centre National de la Recherche Scientifique (CNRS) UMR5310  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1, 69000 Lyon France and University Jean Monnet  Saint\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Camdessanch\u00e9","sequence":"additional","affiliation":[{"name":"MeLiS | CNRS UMR 5284 | INSERM U1314, Synaptopathies and Autoantibodies, Institut National de La Sant\u00e9 et De La Recherche M\u00e9dicale (INSERM), U1217 Centre National de la Recherche Scientifique (CNRS) UMR5310  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1, 69000 Lyon France and University Jean Monnet  Saint\u2010Priest\u2010en\u2010Jarez France"},{"name":"Department of Neurology University Hospital of Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Antoine","sequence":"additional","affiliation":[{"name":"MeLiS | CNRS UMR 5284 | INSERM U1314, Synaptopathies and Autoantibodies, Institut National de La Sant\u00e9 et De La Recherche M\u00e9dicale (INSERM), U1217 Centre National de la Recherche Scientifique (CNRS) UMR5310  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1, 69000 Lyon France and University Jean Monnet  Saint\u2010Priest\u2010en\u2010Jarez France"},{"name":"Department of Neurology University Hospital of Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Honnorat","sequence":"additional","affiliation":[{"name":"MeLiS | CNRS UMR 5284 | INSERM U1314, Synaptopathies and Autoantibodies, Institut National de La Sant\u00e9 et De La Recherche M\u00e9dicale (INSERM), U1217 Centre National de la Recherche Scientifique (CNRS) UMR5310  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1, 69000 Lyon France and University Jean Monnet  Saint\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jafar","family":"Kafaie","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Saint Louis University School of Medicine  Saint Louis Missouri USA"},{"name":"Institute For Translational Neuroscience Saint Louis University School of Medicine  Saint Louis Missouri USA"},{"name":"Department of Neurology Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liberty","family":"Fran\u00e7ois\u2010Moutal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Saint Louis University School of Medicine  Saint Louis Missouri USA"},{"name":"Institute For Translational Neuroscience Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-1206","authenticated-orcid":false,"given":"Aubin","family":"Moutal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Saint Louis University School of Medicine  Saint Louis Missouri USA"},{"name":"Institute For Translational Neuroscience Saint Louis University School of Medicine  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(17)30329\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10181"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12298"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2917"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23910"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1533\u20102500.2001.01016.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13508"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102014\u2010309730"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26748"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102019\u2010321849"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1181"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.11.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010024\u201003031\u20101"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201879"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102530"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201024\u20100012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003928"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577757"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2019.01.004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay7550"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002970"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac153"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024241281493"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010024\u201003123\u20103"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2501229122"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2951"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae179"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003743"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.05.04.592533"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38017"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003470"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3791\/56857"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1690918"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20100270(94)90144\u20109"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj8186"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001973"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj9173"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010024\u201001857\u20102"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062380\u2010y"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000555"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324019111"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2022.02.009"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2428\u201010.2010"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001002"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092696"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adj1277"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1254854"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0000000000000485"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27846"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27745"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27800"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.10.006"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.3252"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)78276\u20106"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010011\u20100578\u20103"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202302259RR"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2025.578559"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4403\u201007.2008"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3858\u201005.2006"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4872\u201009.2010"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744\u20108069\u20108\u20106"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000535552"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113685"},{"issue":"8","key":"e_1_2_9_65_1","first-page":"2898","article-title":"Spinal Astrocytic FGFR3 Activation Leads to Mechanical Hypersensitivity by Increased TNF\u2010\ud835\udefc in Spared Nerve Injury","volume":"12","author":"Xie K. Y.","year":"2019","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103959(00)00276\u20101"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm970367n"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.08.026"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115453"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202511413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202511413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202511413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T09:00:30Z","timestamp":1776416430000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202511413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":68,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/advs.202511413"],"URL":"https:\/\/doi.org\/10.1002\/advs.202511413","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"assertion":[{"value":"2025-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e11413"}}