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Here, we introduce \u03c650 \u00b5m molybdenum (Mo) wire braided implants that integrate procedural efficacy with biological safety. Mo demonstrates negligible hemolysis (&lt;5%), platelet\u2010inert surfaces, and preserved coagulation kinetics, together with robust cytocompatibility across neurovascular unit cells (endothelia, astrocytes, neurons) under both physiological and ischemia\u2013reperfusion conditions. In vivo, Mo stent wires implanted in rodent carotids maintained blood homeostasis, organ integrity, and neurological function without systemic toxicity. Moreover, braided 2D Mo coils achieved durable aneurysm occlusion with controlled inflammatory resolution and progressive endothelialization, closely resembling clinical performance. Importantly, Mo ions showed no detectable accumulation in brain, kidney, lung, or spleen, attributable to renal clearance and blood\u2013brain barrier selectivity. By coupling intrinsic radiopacity with homogeneous, moderate corrosion, Mo addresses long\u2010standing limitations of existing biodegradable alloys. These findings position Mo as a transformative candidate for next\u2010generation neurovascular devices, harmonizing biodegradability, safety, and imaging precision to redefine the management of both ischemic and hemorrhagic stroke.<\/jats:p>","DOI":"10.1002\/advs.202511466","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T09:01:03Z","timestamp":1759136463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment"],"prefix":"10.1002","volume":"13","author":[{"given":"Yunong","family":"Shen","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Peking University  Beijing 100871 China"},{"name":"China\u2010America Institute of Neuroscience of Xuanwu Hospital Beijing Institute for Brain Disorders Capital Medical 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