{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:32:58Z","timestamp":1788492778227,"version":"build-2803163510"},"reference-count":83,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG066171"],"award-info":[{"award-number":["R01AG066171"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG075807"],"award-info":[{"award-number":["R21AG075807"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["202360054"],"award-info":[{"award-number":["202360054"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In addition to dementia, Alzheimer's patients suffer from sleep impairments and aberrations in sleep\u2010dependent brain rhythms. Deficits in inhibitory GABAergic interneuron function disrupt one of those rhythms, slow oscillation in particular, and actively contribute to Alzheimer's progression. The degree to which transplantation of healthy donor interneuron progenitors restores slow oscillation rhythm in young APP\/PS1 mice is tested. Medial ganglionic eminence (MGE) progenitors are harvested from mouse embryos and transplanted them into host APP\/PS1 mutant cortices. 3D light\u2010sheet and structured illumination microscopy revealed that transplanted MGE progenitors survived and matured into healthy interneurons. In vivo multiphoton calcium imaging and voltage\u2010sensitive dye imaging showed functional integration and slow oscillation rescue in the absence or presence of optogenetic stimulation. The work provides proof\u2010of\u2010concept evidence that stem cell therapy may serve as a viable strategy to rescue functional impairments in cortical circuits of APP\/PS1 mice and potentially those of Alzheimer's patients.<\/jats:p>","DOI":"10.1002\/advs.202511472","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T04:09:21Z","timestamp":1764302961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4096-9695","authenticated-orcid":false,"given":"Shinya","family":"Yokomizo","sequence":"first","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megi","family":"Maci","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April M.","family":"Stafford","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Human Development Michigan State University  Grand Rapids MI 49503 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Perle","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusaku","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Brown\u2010Harding","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology and Harvard Center for Biological Imaging Harvard University  Cambridge MA 02138 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology and Harvard Center for Biological Imaging Harvard University  Cambridge MA 02138 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Lovely","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology and Harvard Center for Biological Imaging Harvard University  Cambridge MA 02138 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa","family":"Algamal","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Gillani","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore J.","family":"Zwang","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology and Harvard Center for Biological Imaging Harvard University  Cambridge MA 02138 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice R.","family":"Naegele","sequence":"additional","affiliation":[{"name":"Department of Biology Program in Neuroscience and Behavior Hall\u2010Atwater Laboratory Wesleyan University  Middletown CT 06459 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Human Development Michigan State University  Grand Rapids MI 49503 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3727-0317","authenticated-orcid":false,"given":"Ksenia V.","family":"Kastanenka","sequence":"additional","affiliation":[{"name":"Department of Neurology MassGeneral Institute of Neurodegenerative Diseases Mass General Brigham and Harvard Medical School  Charlestown MA 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12068"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002369"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3463\u201009.2009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4140\/TCP.n.2024.75"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010024\u201000611\u20105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100708"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/03946320231209839"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pcn5.185"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.269"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105031"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26641"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000617\u20104"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab272"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S135561771200001X"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2004.12.005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2017.00092"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170275"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000682\u20109"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201044964\u2010z"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004291"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1303\u201017.2017"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1631\u201022.2022"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201004268\u2010x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.046"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001444\u20100"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00705"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1440334"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/15357597231213161"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000206002"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010017\u20100567\u20105"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.001"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1540\u201006.2006"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2016.11.005"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.05.018"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0693\u201014.2014"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010200010"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389\u20100344(01)00067\u20103"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1954"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.030"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022376"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","unstructured":"S.Grosser F. J.Barreda P.Beed D.Schmitz S. A.Booker I.Vida eNeuro2021 8 ENEURO0354\u201020.2020 https:\/\/doi.org\/10.1523\/ENEURO.0354\u201020.2020.","DOI":"10.1523\/ENEURO.0354-20.2020"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002539"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.010"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010011\u20100058\u20109"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3392"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896\u20106273(03)00065\u20105"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/79848"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1318\u201004.2004"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13\u201008\u201003252.1993"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.227462"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100638\u20102"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22\u201019\u201008691.2002"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4579\u201012.2013"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0005-14.2014"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201014699\u2010w"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgaf077"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201052478\u20106"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.01.004"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11523"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21772"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3055\u201006.2007"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1063\u201019.2019"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.06.020"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368909X470829"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2022.108520"},{"key":"e_1_2_9_67_1","doi-asserted-by":"crossref","unstructured":"J.Gupta M.Bromwich J.Radell M. N.Arshad S.Gonzalez B. W.Luikart G. B.Aaron J. R.Naegele eNeuro2019 6 ENEURO0110\u201018.2019 https:\/\/doi.org\/10.1523\/ENEURO.0110\u201018.2019.","DOI":"10.1523\/ENEURO.0110-18.2019"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.062"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201073082\u20108"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201040402\u20103"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1253\u201018.2019"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814185115"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.06.010"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.08.013"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.04.005"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/15357597251318571"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.01.035"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.01.003"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230527"},{"key":"e_1_2_9_80_1","volume":"98","author":"Vogt D.","year":"2015","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.84112"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010021\u201000080\u20109"},{"key":"e_1_2_9_83_1","first-page":"10","volume":"176","author":"Tu L.","year":"2021","journal-title":"Journal of Visualized Experiments"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202511472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202511472","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202511472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:10:05Z","timestamp":1770970205000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202511472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":83,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/advs.202511472"],"URL":"https:\/\/doi.org\/10.1002\/advs.202511472","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"assertion":[{"value":"2025-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e11472"}}