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While DRG neuron diversity is well established, SGC heterogeneity remains poorly defined. Here, the first comprehensive in situ characterization of SGC heterogeneity within the mouse DRG is presented. By integrating single\u2010cell RNA sequencing with immunohistochemistry, in situ hybridization, and advanced imaging techniques, four distinct SGC subtypes are identified, validated, and spatially mapped within their native anatomical context: 1) The predominant perisomatic sheaths are defined by marker proteins traditionally used to characterize the entire SGC population, including FABP7, KIR4.1, GS, and CX43. 2) OCT6\n                    <jats:sup>+<\/jats:sup>\n                    SGCs are occasionally found in mosaic perisomatic sheaths, and commonly ensheathing initial axon segments. 3) SCN7A\n                    <jats:sup>+<\/jats:sup>\n                    SGCs lacking traditional markers and forming specialized sheaths around nonpeptidergic neurons, suggesting a role in itch signaling. 4) Interferon response gene\u2010expressing SGCs, responding to Herpes Simplex Virus, suggesting potential involvement in antiviral protection. Finally, human DRG is investigated and distinct inner and outer perisomatic layers with differential expression of markers are observed. The results provide novel insight into SGC heterogeneity, suggesting distinct functional properties for such subtypes of relevance for the neuronal microenvironment.\n                  <\/jats:p>","DOI":"10.1002\/advs.202511569","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:10:14Z","timestamp":1761311414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion"],"prefix":"10.1002","volume":"13","author":[{"given":"Ole Andreas","family":"Ahlgreen","sequence":"first","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads W\u00fcrgler","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Baake","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Engelbrecht","family":"Hybel","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachele","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishwarya","family":"Sankaranarayanan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Center for Advanced Pain Studies School of Behavioral and Brain Sciences University of Texas at Dallas  Richardson TX 75080 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne Amalie","family":"Pold","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Reinert","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Riis","family":"Paludan","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore John","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Center for Advanced Pain Studies School of Behavioral and Brain Sciences University of Texas at Dallas  Richardson TX 75080 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone Tjener","family":"Pallesen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6573-146X","authenticated-orcid":false,"given":"Christian Bjerggaard","family":"V\u00e6gter","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"65","volume":"226","author":"Pannese E.","year":"2018","journal-title":"Adv. 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