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Here, it is demonstrated that brief, non\u2010invasive abdominal PBMT with 980\u00a0nm light (0.1 J\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) substantially improves endurance by preserving gut epithelial integrity and modulating microbiota. In graded treadmill protocols under anaerobic stress, combined abdomen\u2010and\u2010legs PBMT nearly doubles time to exhaustion versus sham by day 20 (70.23 vs 32.38 min;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001) and remains superior at day 30 (55.56 vs 32.38 min;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001). PBMT preserves mitochondrial cristae and mass in gastrocnemius and soleus muscles (\n                    <jats:italic>P<\/jats:italic>\n                    \u2264 0.0018), achieving a fourfold increase over sham (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001). Abdominal PBMT maintains seven major gut phyla disrupted by intense exercise, enriches SCFA\u2010producing taxa, reduces pathobionts, and elevates circulating and fecal butyrate, spermidine, L\u2010carnitine, and acetylL\u2010carnitine (all\n                    <jats:italic>P<\/jats:italic>\n                    \u2264 0.0001).\n                    <jats:italic>Ex vivo<\/jats:italic>\n                    assays under anaerobic, acidic conditions confirm PBMT\u2010driven expansion of key anaerobes (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05\u20130.0001). In a lactic\u2010acidosis model, abdominal PBMT reduces peak weight loss (\u22485% vs \u224810%) and accelerates recovery. These findings establish abdominal PBMT as a non\u2010invasive modality that reverses epithelial injury and dysbiosis, revealing translational potential for enhancing performance, rehabilitation, and managing disorders associated with dysbiosis or mitochondrial dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/advs.202511582","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:45:37Z","timestamp":1758624337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-6792","authenticated-orcid":false,"given":"Prabhat","family":"Upadhyay","sequence":"first","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital Department of Dermatology Harvard Medical School  50 Blossom Street Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmita","family":"Banstola","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital Department of Dermatology Harvard Medical School  50 Blossom Street Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brijesh","family":"Bhayana","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital Department of Dermatology Harvard Medical School  50 Blossom Street Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5456-5283","authenticated-orcid":false,"given":"Mei X.","family":"Wu","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital Department of Dermatology Harvard Medical School  50 Blossom Street Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2020"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.194"},{"key":"e_1_2_10_3_1","volume":"4","author":"Chen S.","year":"2023","journal-title":"Innovation"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi6329"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900603"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46116-y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3934\/biophy.2017.3.337"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202100246"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2021.112152"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2019.4628"},{"key":"e_1_2_10_11_1","first-page":"386","volume":"16","author":"Jahani\u2010Sherafat S.","year":"2023","journal-title":"Gastroenterol. 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