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Herein, a synergistic anti\u2010cancer therapy leveraging the benefits of physical tumor treating fields (TTFs) and dynamic piezocatalytic therapy (PCT) is presented, aiming to offer an optimized scheme while minimizing systemic side effects. First, a wearable ultrasound\u2010induced wireless energy harvester based on biocompatible lead\u2010free potassium sodium niobate\u2010based piezocomposites is developed to enable efficient acoustic\u2010to\u2010electric conversion. The flexible printed circuit board architecture with two pairs of half\u2010ring electrodes not only generates wide\u2010anging alternating electric fields but also facilitates easy fixation and wearability. Second, biocompatible piezoelectric nanoparticles (NPs) serve as the piezocatalysts to promote the generation of reactive oxygen species (ROS) and to directly interfere with biological processes. Finally, in vivo evaluations using mouse models demonstrate that the combination of ultrasound\u2010activated PCT and TTFs significantly inhibits tumor growth and modulates the tumor immune microenvironment. Notably, prominent synergistic antitumor effects are also observed in patient\u2010derived xenograft (PDX) models of head and neck squamous cell carcinoma (HNSCC), highlighting a versatile approach to advance cancer treatment.<\/jats:p>","DOI":"10.1002\/advs.202511604","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T12:30:36Z","timestamp":1760445036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synergistic Anti\u2010Cancer Therapy Through Ultrasound\u2010Induced Piezocatalytic Therapy and Tumor Treatment Fields"],"prefix":"10.1002","volume":"13","author":[{"given":"Jing","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Biotherapy Cancer Center West China Hospital Sichuan University  Chengdu 610041 China"},{"name":"Department of Obstetrics and Gynecology West China Second University Hospital of Sichuan University  Chengdu Sichuan 610041 China"},{"name":"Sichuan Provincial Key Laboratory of Nuclear Physics and Medical Research Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center West China Hospital Sichuan University  Chengdu 610041 China"},{"name":"Sichuan Provincial Key Laboratory of Nuclear Physics and Medical Research Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Cancer Center West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center West China Hospital Sichuan University  Chengdu 610041 China"},{"name":"Sichuan Provincial Key Laboratory of Nuclear Physics and Medical Research Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Hu","sequence":"additional","affiliation":[{"name":"West China School of Nursing West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiming","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiagang","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-718X","authenticated-orcid":false,"given":"Xingchen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center West China Hospital Sichuan University  Chengdu 610041 China"},{"name":"Sichuan Provincial Key Laboratory of Nuclear Physics and Medical Research Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.18718"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702916104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000250"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1117"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00344-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.09.010"},{"key":"e_1_2_9_8_1","author":"Picozzi V.","year":"2021","journal-title":"J. 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