{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:56:38Z","timestamp":1789080998364,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020743","name":"Institute of Energy, Hefei Comprehensive National Science Center","doi-asserted-by":"publisher","award":["21KZS219"],"award-info":[{"award-number":["21KZS219"]}],"id":[{"id":"10.13039\/100020743","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017668","name":"Anhui Provincial Key Research and Development Plan","doi-asserted-by":"publisher","award":["2022107020013"],"award-info":[{"award-number":["2022107020013"]}],"id":[{"id":"10.13039\/501100017668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2408085ME143"],"award-info":[{"award-number":["2408085ME143"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Direct and efficient methane oxidation to methanol is an appealing route for upgrading abundant methane resources while acquiring building blocks of clean fuels and chemicals. However, owing to its highly symmetrical nature imparted chemical stability and steric hindrance, the design of multi\u2010\u00e5ngstrom (&lt;3.0 \u00c5) spaced active species capable of activating its first C\u2212H bond remains a fundamental challenge. Herein, Cu\u2212Ni dual\u2010atom Pair is constructed using defect engineering and a stepwise deposition method over indium oxide to precisely modulate the C\u2212H polarization with the\u00a0Cu atom showing affinity to H end and Ni anchoring the C side. The optimal CuNi\/InNT achieves an oxygenates (CH\n                    <jats:sub>3<\/jats:sub>\n                    OH and CH\n                    <jats:sub>3<\/jats:sub>\n                    OOH) productivity of 106 mmol\u00a0g\n                    <jats:sub>cat<\/jats:sub>\n                    \u00a0h\n                    <jats:sup>\u22121<\/jats:sup>\n                    , surpassing reported systems. Theoretical calculations validate the dominating role of interatomic distance for methane activation. Specifically, the dual\u2010atom orbital coupling effect in the minimally spaced Cu\u2212Ni pair up\u2010shifts the overall d\u2010band center, significantly enhancing its hybridization with C\/O 2p. Further modification through macroscopic reactor design boosts CH\n                    <jats:sub>3<\/jats:sub>\n                    OH yield to 36818.84 \u00b5mol\u00a0g\n                    <jats:sub>cat<\/jats:sub>\n                    \u00a0h\n                    <jats:sup>\u22121<\/jats:sup>\n                    with 79.37% selectivity in a 1000 mL semi\u2010industrial prototype. This work provides a comprehensive explanation of the Cu\u2212Ni synergy, bridging atomic\u2010scale catalysis with reactor design, and establishes a common design principle for binary catalysts at the electron and orbital level.\n                  <\/jats:p>","DOI":"10.1002\/advs.202511661","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T13:05:56Z","timestamp":1754917556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Orchestrating Multi\u2010\u00c5ngstrom Spaced Cu\u2500Ni Dual\u2010Atom Pair for Synergistic C\u2500H Activation in Direct Methane Oxidation to Methanol"],"prefix":"10.1002","volume":"12","author":[{"given":"Jingting","family":"Jin","sequence":"first","affiliation":[{"name":"Laboratory of Clean Low\u2010Carbon Energy University of Science and Technology of China  Hefei 230023 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-4555","authenticated-orcid":false,"given":"Wenzhi","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Clean Low\u2010Carbon Energy University of Science and Technology of China  Hefei 230023 P. R. China"},{"name":"Institute of Energy Hefei Comprehensive National Science Center  Hefei 230031 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Clean Low\u2010Carbon Energy University of Science and Technology of China  Hefei 230023 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemical and Blasting Engineering Anhui University of Science and Technology  Huainan 232001 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Clean Low\u2010Carbon Energy University of Science and Technology of China  Hefei 230023 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pecs.2016.04.003"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35251F"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-022-00422-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00439"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00709D"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00727"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-018-0170-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja058466a"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enchem.2020.100050"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/b805427d"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2021.01.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00417"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-023-01051-x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00624"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01291B"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5EE03372A"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19059"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00344"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c09141"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302143"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.215961"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2023.123156"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408364"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.149904"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2021.120384"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03866"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40415-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30434-0"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08992"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07018"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12843-w"},{"key":"e_1_2_7_32_1","volume":"35","author":"Dedong H.","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2022.121202"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2018.08.058"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba6435"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202203001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202305530"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b08821"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2020.119602"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.122017"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201803241"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b05520"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42285-4"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3991(98)00035-7"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2019.04.046"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2014.01.085"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c09921"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105656"},{"key":"e_1_2_7_49_1","first-page":"11","volume":"17","author":"Xing W.","year":"2024","journal-title":"Nano\u2010Micro Lett."}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202511661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:54:54Z","timestamp":1762422894000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202511661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":49,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/advs.202511661"],"URL":"https:\/\/doi.org\/10.1002\/advs.202511661","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2025-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e11661"}}