{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:49:41Z","timestamp":1792856981398,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Postoperative abdominal adhesions are the most common complication following abdominopelvic surgery, posing a significant burden on patients, clinicians, and society. However, current physical barriers often involve a tradeoff between preventing these adhesions and inhibiting inflammation. Herein, a one\u2010stone\u2010two\u2010birds strategy is presented to address this challenge through an injectable intertwined hydrogel containing sulfobetaine, modified aminocaproic acid (A6ACA), and ZnO nanoparticles (PSA\u2010ZnO hydrogel). This intertwined network is stabilized by multiple intermolecular coordination bonds, including hydrogen bonds and electrostatic interactions\u2014enabling facile injection and resistance to abdominal creep stress. Experimental results demonstrate that PSA\u2010ZnO hydrogel fully reduce the severity of peritoneal adhesions in treated rats at both 7\u2010 and 14\u2010days post\u2010surgery, outperforming commercially available hyaluronic acid (HA) gel due to its superior antifouling, antibacterial (&gt; 95% clearance of\n                    <jats:italic>E. coli<\/jats:italic>\n                    and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ,), hemostatic (55 s), and wound healing properties (IL\u20106 and TNF\u2010\u03b1 decreased and VEGF increased). Unlike conventional barriers, PSA\u2010ZnO prevents foreign body formation by inhibiting blood clot organization and pathologic fibrin accumulation at wound sites. This integrated approach offers a clinically translatable solution for complete prevention of postoperative adhesions and inflammation, with the potential to improve patient outcomes and reduce healthcare burdens.\n                  <\/jats:p>","DOI":"10.1002\/advs.202511757","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:20:16Z","timestamp":1755598816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An Injectable Zwitterionic Hydrogels with Multiple Intermolecular Interactions for Effective Prevention of Abdominal Adhesions"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8293-6042","authenticated-orcid":false,"given":"Na","family":"Wen","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Fuzhou University  Fuzhou 350116 China"},{"name":"State Key Laboratory of Chemistry for NBC Hazards Protection, State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou University  Fuzhou 350108 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Fuzhou University  Fuzhou 350116 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhao","family":"Song","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Fuzhou University  Fuzhou 350116 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachao","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Fuzhou University  Fuzhou 350116 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemistry for NBC Hazards Protection, State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou University  Fuzhou 350108 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemistry for NBC Hazards Protection, State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou University  Fuzhou 350108 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunbin","family":"Yu","sequence":"additional","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital  Fuzhou Fujian 350001 China"},{"name":"Shengli Clinical Medical College Fujian Medical University  Fuzhou Fujian 350001 China"},{"name":"Department of Pathology Fujian Provincial Hospital  Fuzhou Fujian 350001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital  Fuzhou Fujian 350001 China"},{"name":"Shengli Clinical Medical College Fujian Medical University  Fuzhou Fujian 350001 China"},{"name":"Department of Gastroenterology Fujian Provincial Hospital  Fuzhou Fujian 350001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fujian 350002 P. 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