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However, current skin models often lack patient specificity and fail to recapitulate native extracellular matrix (ECM) composition, limiting their clinical relevance. This study presents a 3D\u2010bioprinted skin model using a patient\u2010derived decellularized ECM (pddECM) bioink combined with keratin\u2010alginate (KA) bioink, mimicking native skin architecture and function. The pddECM supports high viability of human dermal fibroblasts (HDFs), promoting collagen I production and robust ECM remodeling, while the KA bioink enhances basal keratinocyte activation and cornification. The construct exhibits improved cell migration and angiogenesis, contributing to effective tissue integration and reduced hypoxic stress. Cytokine profiling reveals upregulation of ICAM\u20101 and complement C5, which are associated with enhanced keratinocyte motility and rapid matrix remodeling, while downregulation of pro\u2010inflammatory cytokines (IL\u20104 and IL\u20108) suggests a favorable, fibrosis\u2010suppressive environment. In vivo, GelMA and GelMA+pddECM scaffolds accelerated wound closure without local or systemic toxicity, preserving dermal thickness and inducing migrating epidermal tongue (MET) expression. This patient\u2010specific, bioactive skin model holds strong potential as a next\u2010generation platform for personalized wound healing, drug screening, and high\u2010fidelity skin grafting in translational tissue engineering.<\/jats:p>","DOI":"10.1002\/advs.202511889","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T09:59:16Z","timestamp":1758794356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bioengineered Skin Grafts from Patient\u2010Derived Decellularized Extracellular Matrix and Autologous Cells for Personalized Regenerative"],"prefix":"10.1002","volume":"12","author":[{"given":"RaeHui","family":"Kang","sequence":"first","affiliation":[{"name":"Division of Interdisciplinary Bioscience &amp; Bioengineering Pohang University of Science and Technology (POSTECH)  Pohang 37666 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyeon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH)  Pohang 37666 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurim","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH)  Pohang 37666 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WonJun","family":"Jang","sequence":"additional","affiliation":[{"name":"Interdisciplinary Major Program in Innovative Pharmaceutical Sciences Korea University  Sejong 30019 Republic of Korea"},{"name":"College of Pharmacy Korea University  Sejong 30019 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soojin","family":"Park","sequence":"additional","affiliation":[{"name":"Interdisciplinary Major Program in Innovative Pharmaceutical Sciences Korea University  Sejong 30019 Republic of Korea"},{"name":"College of Pharmacy Korea University  Sejong 30019 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery School of Medicine Ewha Womans University  Seoul 03760 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Jong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pharmacy College of Pharmacy Kangwon National University  Chuncheon 24341 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Shrike","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-7238","authenticated-orcid":false,"given":"Han\u2010Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Interdisciplinary Major Program in Innovative Pharmaceutical Sciences Korea University  Sejong 30019 Republic of Korea"},{"name":"College of Pharmacy Korea University  Sejong 30019 Republic of Korea"},{"name":"Department of Plastic and Reconstructive Surgery College of Medicine, Korea University  Seoul 02841 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery School of Medicine Ewha Womans University  Seoul 03760 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-7130","authenticated-orcid":false,"given":"Junmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Interdisciplinary Bioscience &amp; 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